| Chapter title |
Anxiety and Epigenetics
|
|---|---|
| Chapter number | 8 |
| Book title |
Neuroepigenomics in Aging and Disease
|
| Published in |
Advances in experimental medicine and biology, May 2017
|
| DOI | 10.1007/978-3-319-53889-1_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953888-4, 978-3-31-953889-1
|
| Authors |
Bartlett, Andrew A., Singh, Rumani, Hunter, Richard G., Andrew A. Bartlett, Rumani Singh Ph.D., Richard G. Hunter Ph.D., Rumani Singh, Richard G. Hunter |
| Editors |
Raul Delgado-Morales |
| Abstract |
Anxiety disorders are highly prevalent psychiatric disorders often comorbid with depression and substance abuse. Twin studies have shown that anxiety disorders are moderately heritable. Yet, genome-wide association studies (GWASs) have failed to identify gene(s) significantly associated with diagnosis suggesting a strong role for environmental factors and the epigenome. A number of anxiety disorder subtypes are considered "stress related." A large focus of research has been on the epigenetic and anxiety-like behavioral consequences of stress. Animal models of anxiety-related disorders have provided strong evidence for the role of stress on the epigenetic control of the hypothalamic-pituitary-adrenal (HPA) axis and of stress-responsive brain regions. Neuroepigenetics may continue to explain individual variation in susceptibility to environmental perturbations and consequently anxious behavior. Behavioral and pharmacological interventions aimed at targeting epigenetic marks associated with anxiety may prove fruitful in developing treatments. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Italy | 1 | 17% |
| Brazil | 1 | 17% |
| France | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 189 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 28 | 15% |
| Student > Bachelor | 28 | 15% |
| Student > Ph. D. Student | 19 | 10% |
| Researcher | 15 | 8% |
| Student > Doctoral Student | 15 | 8% |
| Other | 25 | 13% |
| Unknown | 59 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 14% |
| Psychology | 18 | 10% |
| Neuroscience | 18 | 10% |
| Biochemistry, Genetics and Molecular Biology | 15 | 8% |
| Nursing and Health Professions | 10 | 5% |
| Other | 29 | 15% |
| Unknown | 73 | 39% |