| Chapter title |
Asymmetries and Symmetries in the Mouse Oocyte and Zygote
|
|---|---|
| Chapter number | 13 |
| Book title |
Asymmetric Cell Division in Development, Differentiation and Cancer
|
| Published in |
Results and problems in cell differentiation, April 2017
|
| DOI | 10.1007/978-3-319-53150-2_13 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953149-6, 978-3-31-953150-2
|
| Authors |
Agathe Chaigne, Marie-Emilie Terret, Marie-Hélène Verlhac |
| Editors |
Jean-Pierre Tassan, Jacek Z. Kubiak |
| Abstract |
Mammalian oocytes grow periodically after puberty thanks to the dialogue with their niche in the follicle. This communication between somatic and germ cells promotes the accumulation, inside the oocyte, of maternal RNAs, proteins and other molecules that will sustain the two gamete divisions and early embryo development up to its implantation. In order to preserve their stock of maternal products, oocytes from all species divide twice minimizing the volume of their daughter cells to their own benefit. For this, they undergo asymmetric divisions in size where one main objective is to locate the division spindle with its chromosomes off-centred. In this chapter, we will review how this main objective is reached with an emphasis on the role of actin microfilaments in this process in mouse oocytes, the most studied example in mammals. This chapter is subdivided into three parts: I-General features of asymmetric divisions in mouse oocytes, II-Mechanism of chromosome positioning by actin in mouse oocytes and III-Switch from asymmetric to symmetric division at the oocyte-to-embryo transition. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 29% |
| Researcher | 3 | 13% |
| Student > Bachelor | 3 | 13% |
| Student > Master | 2 | 8% |
| Student > Doctoral Student | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 5 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 29% |
| Agricultural and Biological Sciences | 7 | 29% |
| Nursing and Health Professions | 1 | 4% |
| Unspecified | 1 | 4% |
| Medicine and Dentistry | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 6 | 25% |