Chapter title |
Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy.
|
---|---|
Chapter number | 18 |
Book title |
Asymmetric Cell Division in Development, Differentiation and Cancer
|
Published in |
Results and problems in cell differentiation, April 2017
|
DOI | 10.1007/978-3-319-53150-2_18 |
Pubmed ID | |
Book ISBNs |
978-3-31-953149-6, 978-3-31-953150-2
|
Authors |
Mukherjee, Subhas, Brat, Daniel J, Subhas Mukherjee, Daniel J. Brat M.D., Ph.D., Daniel J. Brat |
Editors |
Jean-Pierre Tassan, Jacek Z. Kubiak |
Abstract |
Asymmetric division of stem cells is a highly conserved and tightly regulated process by which a single stem cell produces two unequal daughter cells. One retains its stem cell identity while the other becomes specialized through a differentiation program and loses stem cell properties. Coordinating these events requires control over numerous intra- and extracellular biological processes and signaling networks. In the initial stages, critical events include the compartmentalization of fate determining proteins within the mother cell and their subsequent passage to the appropriate daughter cell in order to direct their destiny. Disturbance of these events results in an altered dynamic of self-renewing and differentiation within the cell population, which is highly relevant to the growth and progression of cancer. Other critical events include proper asymmetric spindle assembly, extrinsic regulation through micro-environmental cues, and non-canonical signaling networks that impact cell division and fate determination. In this review, we discuss mechanisms that maintain the delicate balance of asymmetric cell division in normal tissues and describe the current understanding how some of these mechanisms are deregulated in cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 2 | 22% |
Student > Bachelor | 2 | 22% |
Researcher | 2 | 22% |
Student > Master | 1 | 11% |
Student > Ph. D. Student | 1 | 11% |
Other | 0 | 0% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 33% |
Medicine and Dentistry | 2 | 22% |
Agricultural and Biological Sciences | 2 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
Unknown | 1 | 11% |