| Chapter title |
The Midbody and its Remnant in Cell Polarization and Asymmetric Cell Division.
|
|---|---|
| Chapter number | 7 |
| Book title |
Asymmetric Cell Division in Development, Differentiation and Cancer
|
| Published in |
Results and problems in cell differentiation, April 2017
|
| DOI | 10.1007/978-3-319-53150-2_7 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953149-6, 978-3-31-953150-2
|
| Authors |
Pohl, Christian, Christian Pohl |
| Editors |
Jean-Pierre Tassan, Jacek Z. Kubiak |
| Abstract |
The midbody is a protein-dense assembly that forms during cytokinesis when the actomyosin ring constricts around bundling central spindle microtubules. After its initial description by Walther Flemming in the late nineteenth century and its rediscovery through electron microscopy in the 1960s and 1970s, its ultrastructural organization and the sequential recruitment of its molecular constituents has only been elucidated in the past decade. Recently, it has become clear that the midbody can serve as a polarity cue during asymmetric cell division, cell polarization, and spindle orientation by coordinating cytoskeletal organization, vesicular transport, and localized cortical cues. In this chapter, these newly emerging functions will be discussed as well as asymmetries during midbody formation and their consequences for cellular organization in tissues. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 30% |
| Student > Bachelor | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Other | 1 | 10% |
| Professor > Associate Professor | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 40% |
| Agricultural and Biological Sciences | 3 | 30% |
| Mathematics | 1 | 10% |
| Neuroscience | 1 | 10% |
| Unknown | 1 | 10% |