Chapter title |
Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development.
|
---|---|
Chapter number | 4 |
Book title |
Asymmetric Cell Division in Development, Differentiation and Cancer
|
Published in |
Results and problems in cell differentiation, April 2017
|
DOI | 10.1007/978-3-319-53150-2_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-953149-6, 978-3-31-953150-2
|
Authors |
Lam, Arielle Koonyee, Phillips, Bryan T, Arielle Koonyee Lam, Bryan T. Phillips, Phillips, Bryan T. |
Editors |
Jean-Pierre Tassan, Jacek Z. Kubiak |
Abstract |
Asymmetric cell division is a common mode of cell differentiation during the invariant lineage of the nematode, C. elegans. Beginning at the four-cell stage, and continuing throughout embryogenesis and larval development, mother cells are polarized by Wnt ligands, causing an asymmetric inheritance of key members of a Wnt/β-catenin signal transduction pathway termed the Wnt/β-catenin asymmetry pathway. The resulting daughter cells are distinct at birth with one daughter cell activating Wnt target gene expression via β-catenin activation of TCF, while the other daughter displays transcriptional repression of these target genes. Here, we seek to review the body of evidence underlying a unified model for Wnt-driven asymmetric cell division in C. elegans, identify global themes that occur during asymmetric cell division, as well as highlight tissue-specific variations. We also discuss outstanding questions that remain unanswered regarding this intriguing mode of asymmetric cell division. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 43% |
Tunisia | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Scientists | 2 | 29% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 17% |
Student > Master | 5 | 17% |
Student > Ph. D. Student | 5 | 17% |
Researcher | 2 | 7% |
Unspecified | 2 | 7% |
Other | 3 | 10% |
Unknown | 7 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 31% |
Agricultural and Biological Sciences | 8 | 28% |
Unspecified | 2 | 7% |
Business, Management and Accounting | 1 | 3% |
Physics and Astronomy | 1 | 3% |
Other | 2 | 7% |
Unknown | 6 | 21% |