| Chapter title |
Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development.
|
|---|---|
| Chapter number | 4 |
| Book title |
Asymmetric Cell Division in Development, Differentiation and Cancer
|
| Published in |
Results and problems in cell differentiation, April 2017
|
| DOI | 10.1007/978-3-319-53150-2_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953149-6, 978-3-31-953150-2
|
| Authors |
Lam, Arielle Koonyee, Phillips, Bryan T, Arielle Koonyee Lam, Bryan T. Phillips, Phillips, Bryan T. |
| Editors |
Jean-Pierre Tassan, Jacek Z. Kubiak |
| Abstract |
Asymmetric cell division is a common mode of cell differentiation during the invariant lineage of the nematode, C. elegans. Beginning at the four-cell stage, and continuing throughout embryogenesis and larval development, mother cells are polarized by Wnt ligands, causing an asymmetric inheritance of key members of a Wnt/β-catenin signal transduction pathway termed the Wnt/β-catenin asymmetry pathway. The resulting daughter cells are distinct at birth with one daughter cell activating Wnt target gene expression via β-catenin activation of TCF, while the other daughter displays transcriptional repression of these target genes. Here, we seek to review the body of evidence underlying a unified model for Wnt-driven asymmetric cell division in C. elegans, identify global themes that occur during asymmetric cell division, as well as highlight tissue-specific variations. We also discuss outstanding questions that remain unanswered regarding this intriguing mode of asymmetric cell division. |
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Mendeley readers
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