| Chapter title |
Asymmetric Cell Division in the One-Cell C. elegans Embryo: Multiple Steps to Generate Cell Size Asymmetry.
|
|---|---|
| Chapter number | 5 |
| Book title |
Asymmetric Cell Division in Development, Differentiation and Cancer
|
| Published in |
Results and problems in cell differentiation, April 2017
|
| DOI | 10.1007/978-3-319-53150-2_5 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953149-6, 978-3-31-953150-2
|
| Authors |
Pacquelet, Anne, Anne Pacquelet |
| Editors |
Jean-Pierre Tassan, Jacek Z. Kubiak |
| Abstract |
The first division of the one-cell C. elegans embryo has been a fundamental model in deciphering the mechanisms underlying asymmetric cell division. Polarization of the one-cell zygote is induced by a signal from the sperm centrosome and results in the asymmetric distribution of PAR proteins. Multiple mechanisms then maintain PAR polarity until the end of the first division. Once asymmetrically localized, PAR proteins control several essential aspects of asymmetric division, including the position of the mitotic spindle along the polarity axis. Coordination of the spindle and cytokinetic furrow positions is the next essential step to ensure proper asymmetric division. In this chapter, I review the different mechanisms underlying these successive steps of asymmetric division. Work from the last 30 years has revealed the existence of multiple and redundant regulatory pathways which ensure division robustness. Besides the essential role of PAR proteins, this work also emphasizes the importance of both microtubules and actomyosin throughout the different steps of asymmetric division. |
X Demographics
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| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 23% |
| Student > Bachelor | 4 | 18% |
| Researcher | 4 | 18% |
| Professor | 2 | 9% |
| Student > Doctoral Student | 1 | 5% |
| Other | 3 | 14% |
| Unknown | 3 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Agricultural and Biological Sciences | 6 | 27% |
| Mathematics | 2 | 9% |
| Unspecified | 1 | 5% |
| Medicine and Dentistry | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 18% |