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Promoter Associated RNA

Overview of attention for book
Cover of 'Promoter Associated RNA'

Table of Contents

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    Book Overview
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    Chapter 1 ChIP-seq for the Identification of Functional Elements in the Human Genome
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    Chapter 2 Identification of Candidate Functional Elements in the Genome from ChIP-seq Data
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    Chapter 3 GRO-seq, A Tool for Identification of Transcripts Regulating Gene Expression
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    Chapter 4 NanoCAGE: A Method for the Analysis of Coding and Noncoding 5′-Capped Transcriptomes
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    Chapter 5 Deep Cap Analysis of Gene Expression (CAGE): Genome-Wide Identification of Promoters, Quantification of Their Activity, and Transcriptional Network Inference
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    Chapter 6 Deep-RACE: Comprehensive Search for Novel ncRNAs Associated to a Specific Locus
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    Chapter 7 In Silico Prediction of RNA Secondary Structure
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    Chapter 8 Computational Prediction of RNA-Protein Interactions
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    Chapter 9 Isolation of Nuclear RNA-Associated Protein Complexes
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    Chapter 10 Identification of Long Noncoding RNAs Associated to Human Disease Susceptibility
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    Chapter 11 Targeting Promoter-Associated RNAs by siRNAs
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    Chapter 12 RNA-FISH to Study Regulatory RNA at the Site of Transcription
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    Chapter 13 Detection and Characterization of R Loop Structures
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    Chapter 14 Induction of Transcriptional Gene Silencing by Expression of shRNA Directed to c-Myc P2 Promoter in Hepatocellular Carcinoma by Tissue-Specific Virosomal Delivery
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    Chapter 15 Targeting Promoter-Associated Noncoding RNA In Vivo
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    Chapter 16 Manipulation of Promoter-Associated Noncoding RNAs in Mouse Early Embryos for Controlling Sequence-Specific Epigenetic Status
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    Chapter 17 Erratum to: NanoCAGE: A Method for the Analysis of Coding and Noncoding 5′-Capped Transcriptomes
Attention for Chapter 14: Induction of Transcriptional Gene Silencing by Expression of shRNA Directed to c-Myc P2 Promoter in Hepatocellular Carcinoma by Tissue-Specific Virosomal Delivery
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Chapter title
Induction of Transcriptional Gene Silencing by Expression of shRNA Directed to c-Myc P2 Promoter in Hepatocellular Carcinoma by Tissue-Specific Virosomal Delivery
Chapter number 14
Book title
Promoter Associated RNA
Published in
Methods in molecular biology, March 2017
DOI 10.1007/978-1-4939-6716-2_14
Pubmed ID
28349432
Book ISBNs
978-1-4939-6714-8, 978-1-4939-6716-2
Authors

Mohammad Khalid Zakaria, Debi P. Sarkar, Parthaprasad Chattopadhyay

Editors

Sara Napoli

Abstract

Double-stranded RNA-mediated transcriptional gene silencing (TGS) has shown promising results over posttranscriptional gene silencing (PTGS) due to its long term and heritable nature. Various research groups have shed light on different mechanisms by which TGS operate. Some of these include histone modification, DNA methylation, or restriction of RNA polymerase binding onto the target gene's promoter. This serves as an added advantage since permanent c-Myc inactivation is critical for suppressing hepatocellular carcinoma (HCC). Inability to target cancer cells specifically, without affecting the normal cells, has been one of the biggest drawbacks of an effective cancer therapy. Therefore, we aimed to overcome this barrier by first generating tumor-specific transcriptional units expressing TGS inducing shRNAs against c-Myc's P2 promoter only in neoplastic liver cells. Secondly, we coupled this TGS inducing system with Sendai fusion virosomes for liver-specific delivery to minimize nonspecific side effects in vitro.

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Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 33%
Researcher 2 33%
Professor > Associate Professor 1 17%
Student > Bachelor 1 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 50%
Immunology and Microbiology 1 17%
Medicine and Dentistry 1 17%
Unknown 1 17%

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