Chapter title |
Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease
|
---|---|
Chapter number | 12 |
Book title |
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-3-319-50174-1_12 |
Pubmed ID | |
Book ISBNs |
978-3-31-950172-7, 978-3-31-950174-1
|
Authors |
Yu Cai, Lu Yang, Fang Niu, Ke Liao, Shilpa Buch, Cai, Yu, Yang, Lu, Niu, Fang, Liao, Ke, Buch, Shilpa |
Editors |
Sylvia B. Smith, Tsung-Ping Su |
Abstract |
Sigma-1 receptors (Sig-1R) are recognized as a unique class of non-G protein-coupled intracellular protein. Sig-1R binds to its ligand such as cocaine , resulting in dissociation of Sig-1R from mitochondrion-associated ER membrane (MAM) to the endoplasmic reticulum (ER), plasma membrane, and nuclear membrane, regulating function of various proteins. Sig-1R has diverse roles in both physiological as well as in pathogenic processes. The disruption of Sig-1R pathways has been implicated as causative mechanism(s) in the development of both neurodegenerative disorders such as Alzheimer disease (AD ), Parkinson disease (PD ), amyotrophic lateral sclerosis (ALS ) and Huntington Disease (HD ) . Additionally, the interaction of cocaine and Sig-1R has more recently been implicated in potentiating the pathogenesis of HIV-associated neurocognitive disorders (HAND) through impairment of blood-brain barrier (BBB), microglial activation and astrogliosis. On the other hand, restoration of Sig-1R homeostasis has been shown to exert neuroprotective effects. In this review, we provide an overview of how Sig-1R plays a role in the pathogenesis of neurodegenerative disorders and cocaine and implications for future development of therapeutic strategies. |
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Student > Ph. D. Student | 5 | 10% |
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Other | 7 | 14% |
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Other | 6 | 12% |
Unknown | 17 | 35% |