Chapter title |
Sigma-1 Receptors Fine-Tune the Neuronal Networks
|
---|---|
Chapter number | 7 |
Book title |
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-3-319-50174-1_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-950172-7, 978-3-31-950174-1
|
Authors |
Shang-Yi Anne Tsai, Tsung-Ping Su |
Editors |
Sylvia B. Smith, Tsung-Ping Su |
Abstract |
The endoplasmic reticular (ER) protein sigma-1 receptor (Sig-1R) has been implicated in CNS disorders including but not limited to neurodegenerative diseases, depression , amnesia, and substance abuse. Sig-1Rs are particularly enriched in the specific domain where ER membranes make contacts with the mitochondria (MAM). Within that specific domain, Sig-1Rs play significant roles governing calcium signaling and reactive oxygen species homeostasis to maintain proper neuronal functions. Studies showed that the Sig-1R is pivotal to regulate neuroplasticity and neural survival via multiple aspects of mechanism. Numerous reports have been focusing on Sig-1R's regulatory effects in ER stress, mitochondrial function, oxidative stress and protein chaperoning. In this book chapter, we will discuss the emerging role of Sig-1R in balancing the populations of neuron and glia and their implications in CNS diseases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 25% |
Student > Ph. D. Student | 3 | 15% |
Student > Bachelor | 2 | 10% |
Lecturer > Senior Lecturer | 1 | 5% |
Other | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 25% |
Neuroscience | 5 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Medicine and Dentistry | 1 | 5% |
Psychology | 1 | 5% |
Other | 2 | 10% |
Unknown | 5 | 25% |