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Sigma Receptors: Their Role in Disease and as Therapeutic Targets

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Cover of 'Sigma Receptors: Their Role in Disease and as Therapeutic Targets'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets
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    Chapter 2 Structural Perspectives on Sigma-1 Receptor Function
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    Chapter 3 A Review of the Human Sigma-1 Receptor Structure
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    Chapter 4 Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System
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    Chapter 5 The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target
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    Chapter 6 Sigma 1 Receptor and Ion Channel Dynamics in Cancer
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    Chapter 7 Sigma-1 Receptors Fine-Tune the Neuronal Networks
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    Chapter 8 Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain
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    Chapter 9 Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics
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    Chapter 10 Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection
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    Chapter 11 Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders
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    Chapter 12 Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease
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    Chapter 13 Sigma Receptors and Substance Use Disorders
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    Chapter 14 Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice
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    Chapter 15 Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia
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    Chapter 16 Sigma-1 Receptor in Motoneuron Disease
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    Chapter 17 The Sigma-1 Receptor–A Therapeutic Target for the Treatment of ALS?
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    Chapter 18 The Role of Sigma1R in Mammalian Retina
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    Chapter 19 Peeking into Sigma-1 Receptor Functions Through the Retina
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    Chapter 20 The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma
Attention for Chapter 7: Sigma-1 Receptors Fine-Tune the Neuronal Networks
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Chapter title
Sigma-1 Receptors Fine-Tune the Neuronal Networks
Chapter number 7
Book title
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Published in
Advances in experimental medicine and biology, March 2017
DOI 10.1007/978-3-319-50174-1_7
Pubmed ID
Book ISBNs
978-3-31-950172-7, 978-3-31-950174-1
Authors

Shang-Yi Anne Tsai, Tsung-Ping Su

Editors

Sylvia B. Smith, Tsung-Ping Su

Abstract

The endoplasmic reticular (ER) protein sigma-1 receptor (Sig-1R) has been implicated in CNS disorders including but not limited to neurodegenerative diseases, depression , amnesia, and substance abuse. Sig-1Rs are particularly enriched in the specific domain where ER membranes make contacts with the mitochondria (MAM). Within that specific domain, Sig-1Rs play significant roles governing calcium signaling and reactive oxygen species homeostasis to maintain proper neuronal functions. Studies showed that the Sig-1R is pivotal to regulate neuroplasticity and neural survival via multiple aspects of mechanism. Numerous reports have been focusing on Sig-1R's regulatory effects in ER stress, mitochondrial function, oxidative stress and protein chaperoning. In this book chapter, we will discuss the emerging role of Sig-1R in balancing the populations of neuron and glia and their implications in CNS diseases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 25%
Student > Ph. D. Student 3 15%
Student > Bachelor 2 10%
Lecturer > Senior Lecturer 1 5%
Other 1 5%
Other 1 5%
Unknown 7 35%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 25%
Neuroscience 5 25%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Medicine and Dentistry 1 5%
Psychology 1 5%
Other 2 10%
Unknown 5 25%