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Sigma Receptors: Their Role in Disease and as Therapeutic Targets

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Cover of 'Sigma Receptors: Their Role in Disease and as Therapeutic Targets'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets
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    Chapter 2 Structural Perspectives on Sigma-1 Receptor Function
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    Chapter 3 A Review of the Human Sigma-1 Receptor Structure
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    Chapter 4 Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System
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    Chapter 5 The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target
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    Chapter 6 Sigma 1 Receptor and Ion Channel Dynamics in Cancer
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    Chapter 7 Sigma-1 Receptors Fine-Tune the Neuronal Networks
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    Chapter 8 Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain
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    Chapter 9 Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics
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    Chapter 10 Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection
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    Chapter 11 Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders
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    Chapter 12 Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease
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    Chapter 13 Sigma Receptors and Substance Use Disorders
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    Chapter 14 Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice
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    Chapter 15 Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia
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    Chapter 16 Sigma-1 Receptor in Motoneuron Disease
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    Chapter 17 The Sigma-1 Receptor–A Therapeutic Target for the Treatment of ALS?
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    Chapter 18 The Role of Sigma1R in Mammalian Retina
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    Chapter 19 Peeking into Sigma-1 Receptor Functions Through the Retina
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    Chapter 20 The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma
Attention for Chapter 1: Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets
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Chapter title
Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Chapter number 1
Book title
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Published in
Advances in experimental medicine and biology, March 2017
DOI 10.1007/978-3-319-50174-1_1
Pubmed ID
Book ISBNs
978-3-31-950172-7, 978-3-31-950174-1
Authors

Sylvia B. Smith

Editors

Sylvia B. Smith, Tsung-Ping Su

Abstract

This book highlights contributions from leaders in the field of sigma receptor research. Sigma receptors represent a promising, novel target for the treatment of neurodegenerative diseases, retinal degenerations, pain and substance abuse. Information is presented about tracers for molecular imaging these receptors, the newly determined crystal structure of human sigma 1 receptor and information about sigma 2 receptor. New discoveries about the role of sigma 1 receptors in cancer, pain, neuropsychiatric disorders, learning and memory, neuronal networks and depression are described. The compendium offers important insights about the direction unfolding for this exciting field of research.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 96 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 17%
Researcher 15 16%
Student > Master 11 11%
Student > Bachelor 11 11%
Other 8 8%
Other 13 14%
Unknown 22 23%
Readers by discipline Count As %
Neuroscience 15 16%
Biochemistry, Genetics and Molecular Biology 13 14%
Medicine and Dentistry 13 14%
Pharmacology, Toxicology and Pharmaceutical Science 8 8%
Chemistry 8 8%
Other 13 14%
Unknown 26 27%