Chapter title |
The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma
|
---|---|
Chapter number | 20 |
Book title |
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-3-319-50174-1_20 |
Pubmed ID | |
Book ISBNs |
978-3-31-950172-7, 978-3-31-950174-1
|
Authors |
Barbara Mysona, Neil Kansara, Jing Zhao, Kathryn Bollinger M.D., Ph.D., Kathryn Bollinger |
Editors |
Sylvia B. Smith, Tsung-Ping Su |
Abstract |
The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer's and Parkinson's disease . S1R modulates multiple cellular functions associated with neurodegeneration . These include Ca(2+) ion homeostasis, endoplasmic reticulum (ER) and oxidative stress , survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 14% |
Student > Bachelor | 2 | 10% |
Researcher | 2 | 10% |
Lecturer | 1 | 5% |
Student > Ph. D. Student | 1 | 5% |
Other | 3 | 14% |
Unknown | 9 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 24% |
Neuroscience | 4 | 19% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Agricultural and Biological Sciences | 1 | 5% |
Psychology | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 33% |