Chapter title |
Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice
|
---|---|
Chapter number | 14 |
Book title |
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-3-319-50174-1_14 |
Pubmed ID | |
Book ISBNs |
978-3-31-950172-7, 978-3-31-950174-1
|
Authors |
Kohji Fukunaga, Shigeki Moriguchi, Fukunaga, Kohji, Moriguchi, Shigeki |
Editors |
Sylvia B. Smith, Tsung-Ping Su |
Abstract |
Sigma-1 receptor (Sig-1R) is molecular chaperone regulating calcium efflux from the neuronal endoplasmic reticulum to mitochondria. Recent studies show that Sig-1R stimulation antagonizes depressive-like behaviors in animal models, but molecular mechanisms underlying this effect remain unclear. Here, we focus on the effects of Sig-1R ligands on hippocampal neurogenesis and depressive-like behaviors. Sig-1R stimulation also enhances CaMKII /CaMKIV and protein kinase B (Akt) activities in hippocampus. Therefore, we discuss the fundamental roles of Sig-1R, CaMKII /CaMKIV and protein kinase B (Akt) signaling in amelioration of depressive-like behaviors following Sig-1R stimulation. |
X Demographics
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Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 16% |
Student > Ph. D. Student | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Student > Master | 1 | 4% |
Other | 3 | 12% |
Unknown | 12 | 48% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Psychology | 2 | 8% |
Medicine and Dentistry | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 2 | 8% |
Unknown | 13 | 52% |