| Chapter title |
Structural Perspectives on Sigma-1 Receptor Function
|
|---|---|
| Chapter number | 2 |
| Book title |
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
|
| Published in |
Advances in experimental medicine and biology, March 2017
|
| DOI | 10.1007/978-3-319-50174-1_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-950172-7, 978-3-31-950174-1
|
| Authors |
Assaf Alon, Hayden Schmidt, Sanduo Zheng, Andrew C. Kruse |
| Editors |
Sylvia B. Smith, Tsung-Ping Su |
| Abstract |
The sigma-1 receptor is an enigmatic ER-resident transmembrane protein linked to a variety of human diseases. Although the receptor was first cloned 20 years ago, the molecular structure of the protein and the mechanistic basis for its interaction with drug-like small molecules have remained unclear until recently. The determination of the first crystal structure of human sigma-1 offered the first detailed views of the sigma-1 architecture, and revealed an unusual overall fold with a single transmembrane helix in each protomer. The structure shows an overall trimeric receptor arrangement, and each protomer binds a single ligand molecule at the center of its carboxy-terminal domain. These results offer detailed molecular views of receptor structure, oligomerization, and ligand recognition, providing a framework for the next era of sigma-1 research. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 2 | 13% |
| Professor | 2 | 13% |
| Other | 1 | 6% |
| Student > Ph. D. Student | 1 | 6% |
| Researcher | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 8 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 13% |
| Chemistry | 2 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Neuroscience | 1 | 6% |
| Unknown | 10 | 63% |