Chapter title |
Roles of RUNX in Hypoxia-Induced Responses and Angiogenesis
|
---|---|
Chapter number | 27 |
Book title |
RUNX Proteins in Development and Cancer
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-981-10-3233-2_27 |
Pubmed ID | |
Book ISBNs |
978-9-81-103231-8, 978-9-81-103233-2
|
Authors |
Sun Hee Lee, Sarala Manandhar, You Mie Lee Ph.D., You Mie Lee |
Editors |
Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen |
Abstract |
During the past two decades, Runt domain transcription factors (RUNX1, 2, and 3) have been investigated in regard to their function, structural elements, genetic variants, and roles in normal development and pathological conditions. The Runt family proteins are evolutionarily conserved from Drosophila to mammals, emphasizing their physiological importance. A hypoxic microenvironment caused by insufficient blood supply is frequently observed in developing organs, growing tumors, and tissues that become ischemic due to impairment or blockage of blood vessels. During embryonic development and tumor growth, hypoxia triggers a stress response that overcomes low-oxygen conditions by increasing erythropoiesis and angiogenesis and triggering metabolic changes. This review briefly introduces hypoxic conditions and cellular responses, as well as angiogenesis and its related signaling pathways, and then describes our current knowledge on the functions and molecular mechanisms of Runx family proteins in hypoxic responses, especially in angiogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 22% |
Student > Doctoral Student | 4 | 17% |
Student > Master | 3 | 13% |
Researcher | 3 | 13% |
Student > Bachelor | 2 | 9% |
Other | 1 | 4% |
Unknown | 5 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 26% |
Agricultural and Biological Sciences | 4 | 17% |
Medicine and Dentistry | 3 | 13% |
Neuroscience | 2 | 9% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 7 | 30% |