| Chapter title |
Covalent Modifications of RUNX Proteins: Structure Affects Function
|
|---|---|
| Chapter number | 3 |
| Book title |
RUNX Proteins in Development and Cancer
|
| Published in |
Advances in experimental medicine and biology, March 2017
|
| DOI | 10.1007/978-981-10-3233-2_3 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-103231-8, 978-9-81-103233-2
|
| Authors |
Ezra Blumenthal, Sarah Greenblatt, Guang Huang, Koji Ando, Ye Xu, Stephen D. Nimer, Blumenthal, Ezra, Greenblatt, Sarah, Huang, Guang, Ando, Koji, Xu, Ye, Nimer, Stephen D. |
| Editors |
Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen |
| Abstract |
The RUNX family of transcription factors plays important roles in tissue-specific gene expression. Many of their functions depend on specific post-translational modifications (PTMs), and in this review, we describe how PTMs govern RUNX DNA binding, transcriptional activity, protein stability, cellular localization, and protein-protein interactions. We also report how these processes can be disrupted in disease settings. Finally, we describe how alterations of RUNX1, or the enzymes that catalyze its post-translational modifications, contribute to hematopoietic malignancies. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 29% |
| Student > Master | 2 | 14% |
| Researcher | 2 | 14% |
| Student > Ph. D. Student | 2 | 14% |
| Other | 1 | 7% |
| Other | 2 | 14% |
| Unknown | 1 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 43% |
| Agricultural and Biological Sciences | 3 | 21% |
| Medicine and Dentistry | 3 | 21% |
| Engineering | 1 | 7% |
| Unknown | 1 | 7% |