Chapter title |
Roles of RUNX in Hippo Pathway Signaling
|
---|---|
Chapter number | 26 |
Book title |
RUNX Proteins in Development and Cancer
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-981-10-3233-2_26 |
Pubmed ID | |
Book ISBNs |
978-9-81-103231-8, 978-9-81-103233-2
|
Authors |
Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol, Megan Finch-Edmondson |
Editors |
Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen |
Abstract |
The Runt-domain (RD) transcription factors (RUNX genes) are an important family of transcriptional mediators that interact with a variety of proteins including the Hippo pathway effector proteins, YAP and TAZ. In this chapter we focus on two examples of RUNX-TAZ/YAP interactions that have particular significance in human cancer. Specifically, recent evidence has found that RUNX2 cooperates with TAZ to promote epithelial to mesenchymal transition mediated by the soluble N-terminal ectodomain of E-Cadherin, sE-Cad. Contrastingly, in gastric cancer, RUNX3 acts as a tumor suppressor via inhibition of the YAP-TEAD complex and disruption of downstream YAP-mediated gene transcription and the oncogenic phenotype. The reports highlighted in this chapter add to the growing repertoire of instances of Hippo pathway crosstalk that have been identified in cancer. Elucidation of these increasingly complex interactions may help to identify novel strategies to target Hippo pathway dysregulation in human cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 21% |
Researcher | 3 | 16% |
Student > Ph. D. Student | 2 | 11% |
Student > Doctoral Student | 1 | 5% |
Professor | 1 | 5% |
Other | 4 | 21% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 32% |
Agricultural and Biological Sciences | 3 | 16% |
Unspecified | 1 | 5% |
Chemical Engineering | 1 | 5% |
Psychology | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 32% |