Chapter title |
RUNX in Invertebrates
|
---|---|
Chapter number | 1 |
Book title |
RUNX Proteins in Development and Cancer
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-981-10-3233-2_1 |
Pubmed ID | |
Book ISBNs |
978-9-81-103231-8, 978-9-81-103233-2
|
Authors |
S. Hughes, A. Woollard |
Editors |
Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen |
Abstract |
Runx genes have been identified in all metazoans and considerable conservation of function observed across a wide range of phyla. Thus, insight gained from studying simple model organisms is invaluable in understanding RUNX biology in higher animals. Consequently, this chapter will focus on the Runx genes in the diploblasts, which includes sea anemones and sponges, as well as the lower triploblasts, including the sea urchin, nematode, planaria and insect. Due to the high degree of functional redundancy amongst vertebrate Runx genes, simpler model organisms with a solo Runx gene, like C. elegans, are invaluable systems in which to probe the molecular basis of RUNX function within a whole organism. Additionally, comparative analyses of Runx sequence and function allows for the development of novel evolutionary insights. Strikingly, recent data has emerged that reveals the presence of a Runx gene in a protist, demonstrating even more widespread occurrence of Runx genes than was previously thought. This review will summarize recent progress in using invertebrate organisms to investigate RUNX function during development and regeneration, highlighting emerging unifying themes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 33% |
Student > Doctoral Student | 1 | 17% |
Lecturer > Senior Lecturer | 1 | 17% |
Student > Ph. D. Student | 1 | 17% |
Professor > Associate Professor | 1 | 17% |
Other | 0 | 0% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 50% |
Neuroscience | 2 | 33% |
Medicine and Dentistry | 1 | 17% |