Chapter title |
Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth
|
---|---|
Chapter number | 7 |
Book title |
RUNX Proteins in Development and Cancer
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-981-10-3233-2_7 |
Pubmed ID | |
Book ISBNs |
978-9-81-103231-8, 978-9-81-103233-2
|
Authors |
Sayyed K. Zaidi, Jane B. Lian, Andre van Wijnen, Janet L. Stein, Gary S. Stein, Andre J vanWijnen, Zaidi, Sayyed K., Lian, Jane B., Wijnen, Andre van, Stein, Janet L., Stein, Gary S., Wijnen, Andre, van Wijnen, Andre |
Editors |
Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen |
Abstract |
Epigenetic control of gene expression contributes to dynamic responsiveness of cellular processes that include cell cycle, cell growth and differentiation. Mitotic gene bookmarking, retention of sequence-specific transcription factors at target gene loci, including the RUNX regulatory proteins, provide a novel dimension to epigenetic regulation that sustains cellular identity in progeny cells following cell division. Runx transcription factor retention during mitosis coordinates physiological control of cell growth and differentiation in a broad spectrum of biological conditions, and is associated with compromised gene expression in pathologies that include cancer. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 23% |
Researcher | 2 | 9% |
Student > Ph. D. Student | 2 | 9% |
Unspecified | 1 | 5% |
Student > Bachelor | 1 | 5% |
Other | 1 | 5% |
Unknown | 10 | 45% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 36% |
Medicine and Dentistry | 2 | 9% |
Unspecified | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 9 | 41% |