Chapter title |
RUNX1-ETO Leukemia
|
---|---|
Chapter number | 11 |
Book title |
RUNX Proteins in Development and Cancer
|
Published in |
Advances in experimental medicine and biology, March 2017
|
DOI | 10.1007/978-981-10-3233-2_11 |
Pubmed ID | |
Book ISBNs |
978-9-81-103231-8, 978-9-81-103233-2
|
Authors |
Lin, Shan, Mulloy, James C., Goyama, Susumu, Shan Lin, James C. Mulloy, Susumu Goyama |
Editors |
Yoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen |
Abstract |
AML1-ETO leukemia is the most common cytogenetic subtype of acute myeloid leukemia, defined by the presence of t(8;21). Remarkable progress has been achieved in understanding the molecular pathogenesis of AML1-ETO leukemia. Proteomic surveies have shown that AML-ETO forms a stable complex with several transcription factors, including E proteins. Genome-wide transcriptome and ChIP-seq analyses have revealed the genes directly regulated by AML1-ETO, such as CEBPA. Several lines of evidence suggest that AML1-ETO suppresses endogenous DNA repair in cells to promote mutagenesis, which facilitates acquisition of cooperating secondary events. Furthermore, it has become increasingly apparent that a delicate balance of AML1-ETO and native AML1 is important to sustain the malignant cell phenotype. Translation of these findings into the clinical setting is just beginning. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 58 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 16% |
Student > Ph. D. Student | 8 | 14% |
Researcher | 6 | 10% |
Student > Bachelor | 5 | 9% |
Student > Postgraduate | 5 | 9% |
Other | 5 | 9% |
Unknown | 20 | 34% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 21 | 36% |
Medicine and Dentistry | 10 | 17% |
Immunology and Microbiology | 4 | 7% |
Agricultural and Biological Sciences | 2 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 1 | 2% |
Unknown | 19 | 33% |