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Drug Discovery from Mother Nature

Overview of attention for book
Attention for Chapter 9: Potential Use of Flavopiridol in Treatment of Chronic Diseases
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Chapter title
Potential Use of Flavopiridol in Treatment of Chronic Diseases
Chapter number 9
Book title
Drug Discovery from Mother Nature
Published in
Advances in experimental medicine and biology, October 2016
DOI 10.1007/978-3-319-41342-6_9
Pubmed ID
Book ISBNs
978-3-31-941341-9, 978-3-31-941342-6
Authors

Thejal Srikumar, Jaya Padmanabhan

Editors

Subash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal

Abstract

This chapter describes the potential use of flavopiridol, a CDK inhibitor with anti-inflammatory and anti-proliferative activities, in the treatment of various chronic diseases. Flavopiridol arrests cell cycle progression in the G1 or G2 phase by inhibiting the kinase activities of CDK1, CDK2, CDK4/6, and CDK7. Additionally, it binds tightly to CDK9, a component of the P-TEFb complex (CDK9/cyclin T), and interferes with RNA polymerase II activation and associated transcription. This in turn inhibits expression of several pro-survival and anti-apoptotic genes, and enhances cytotoxicity in transformed cells or differentiation in growth-arrested cells. Recent studies indicate that flavopiridol elicits anti-inflammatory activity via CDK9 and NFκB-dependent signaling. Overall, these effects of flavopiridol potentiate its ability to overcome aberrant cell cycle activation and/or inflammatory stimuli, which are mediators of various chronic diseases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 19%
Student > Bachelor 3 19%
Lecturer 2 13%
Student > Master 2 13%
Student > Doctoral Student 1 6%
Other 1 6%
Unknown 4 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 19%
Psychology 2 13%
Engineering 2 13%
Agricultural and Biological Sciences 1 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 2 13%
Unknown 5 31%