| Chapter title |
Potential Use of Flavopiridol in Treatment of Chronic Diseases
|
|---|---|
| Chapter number | 9 |
| Book title |
Drug Discovery from Mother Nature
|
| Published in |
Advances in experimental medicine and biology, October 2016
|
| DOI | 10.1007/978-3-319-41342-6_9 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-941341-9, 978-3-31-941342-6
|
| Authors |
Thejal Srikumar, Jaya Padmanabhan |
| Editors |
Subash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal |
| Abstract |
This chapter describes the potential use of flavopiridol, a CDK inhibitor with anti-inflammatory and anti-proliferative activities, in the treatment of various chronic diseases. Flavopiridol arrests cell cycle progression in the G1 or G2 phase by inhibiting the kinase activities of CDK1, CDK2, CDK4/6, and CDK7. Additionally, it binds tightly to CDK9, a component of the P-TEFb complex (CDK9/cyclin T), and interferes with RNA polymerase II activation and associated transcription. This in turn inhibits expression of several pro-survival and anti-apoptotic genes, and enhances cytotoxicity in transformed cells or differentiation in growth-arrested cells. Recent studies indicate that flavopiridol elicits anti-inflammatory activity via CDK9 and NFκB-dependent signaling. Overall, these effects of flavopiridol potentiate its ability to overcome aberrant cell cycle activation and/or inflammatory stimuli, which are mediators of various chronic diseases. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 19% |
| Student > Bachelor | 3 | 19% |
| Lecturer | 2 | 13% |
| Student > Master | 2 | 13% |
| Student > Doctoral Student | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 4 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 19% |
| Psychology | 2 | 13% |
| Engineering | 2 | 13% |
| Agricultural and Biological Sciences | 1 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
| Other | 2 | 13% |
| Unknown | 5 | 31% |