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Drug Discovery from Mother Nature

Overview of attention for book
Attention for Chapter 15: Drug Discovery from Mother Nature
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Chapter title
Drug Discovery from Mother Nature
Chapter number 15
Book title
Drug Discovery from Mother Nature
Published in
Advances in experimental medicine and biology, October 2016
DOI 10.1007/978-3-319-41342-6_15
Pubmed ID
Book ISBNs
978-3-31-941341-9, 978-3-31-941342-6
Authors

Yamada, Takanori, Sugimoto, Ken, Takanori Yamada, Ken Sugimoto

Editors

Subash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal

Abstract

Guggulsterone is a plant sterol derived from gum resin of Commiphora wightii. The gum resin from guggul plants has been used for thousand years in Ayurveda to treat various disorders, including internal tumors, obesity, liver disorders, malignant sores and ulcers, urinary complaints, intestinal worms, leucoderma, sinuses, edema, and sudden paralytic seizures. Guggulsterone has been identified a bioactive components of this gum resin. This plant steroid has been reported to work as an antagonist of certain nuclear receptors, especially farnesoid X receptor, which regulates bile acids and cholesterol metabolism. Guggulsterone also mediates gene expression through the regulation of transcription factors, including nuclear factor-kappa B and signal transducer and activator of transcription 3, which plays important roles in the development of inflammation and tumorigenesis. Guggulsterone has been shown to downregulate the expression of proteins involved in anti-apoptotic, cell survival, cell proliferation, angiogenic, metastatic, and chemoresistant activities in tumor cells. This review aimed to clarify the cell signal pathways targeted by guggulsterone and the bioactivities of guggulsterone in animal models and humans.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 20%
Student > Doctoral Student 6 12%
Student > Ph. D. Student 6 12%
Student > Master 3 6%
Student > Bachelor 2 4%
Other 6 12%
Unknown 17 34%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 24%
Medicine and Dentistry 6 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Unspecified 2 4%
Agricultural and Biological Sciences 2 4%
Other 4 8%
Unknown 20 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2016.
All research outputs
#20,349,664
of 22,896,955 outputs
Outputs from Advances in experimental medicine and biology
#3,974
of 4,953 outputs
Outputs of similar age
#272,423
of 315,086 outputs
Outputs of similar age from Advances in experimental medicine and biology
#65
of 78 outputs
Altmetric has tracked 22,896,955 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,953 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,086 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.