Report for: Drug Discovery from Mother Nature

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Chapter title	Drug Discovery from Mother Nature
Chapter number	15
Book title	Drug Discovery from Mother Nature
Published in	Advances in experimental medicine and biology, October 2016
DOI	10.1007/978-3-319-41342-6_15
Pubmed ID	27771932
Book ISBNs	978-3-31-941341-9, 978-3-31-941342-6
Authors	Yamada, Takanori, Sugimoto, Ken, Takanori Yamada, Ken Sugimoto
Editors	Subash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal
Abstract	Guggulsterone is a plant sterol derived from gum resin of Commiphora wightii. The gum resin from guggul plants has been used for thousand years in Ayurveda to treat various disorders, including internal tumors, obesity, liver disorders, malignant sores and ulcers, urinary complaints, intestinal worms, leucoderma, sinuses, edema, and sudden paralytic seizures. Guggulsterone has been identified a bioactive components of this gum resin. This plant steroid has been reported to work as an antagonist of certain nuclear receptors, especially farnesoid X receptor, which regulates bile acids and cholesterol metabolism. Guggulsterone also mediates gene expression through the regulation of transcription factors, including nuclear factor-kappa B and signal transducer and activator of transcription 3, which plays important roles in the development of inflammation and tumorigenesis. Guggulsterone has been shown to downregulate the expression of proteins involved in anti-apoptotic, cell survival, cell proliferation, angiogenic, metastatic, and chemoresistant activities in tumor cells. This review aimed to clarify the cell signal pathways targeted by guggulsterone and the bioactivities of guggulsterone in animal models and humans.

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Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	48	100%

Demographic breakdown

Readers by professional status	Count	As %
Researcher	10	21%
Student > Doctoral Student	6	13%
Student > Ph. D. Student	6	13%
Student > Master	3	6%
Student > Bachelor	2	4%
Other	4	8%
Unknown	17	35%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	13	27%
Medicine and Dentistry	6	13%
Pharmacology, Toxicology and Pharmaceutical Science	4	8%
Agricultural and Biological Sciences	2	4%
Computer Science	1	2%
Other	3	6%
Unknown	19	40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2016.

All research outputs

#20,349,664

of 22,896,955 outputs

Outputs from Advances in experimental medicine and biology

#3,974

of 4,953 outputs

Outputs of similar age

#272,423

of 315,086 outputs

Outputs of similar age from Advances in experimental medicine and biology

#65

of 78 outputs

Altmetric has tracked 22,896,955 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.

So far Altmetric has tracked 4,953 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,086 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

Drug Discovery from Mother Nature

Table of Contents

Mentioned by

Citations

Readers on

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context