| Chapter title |
Plumbagin and Its Role in Chronic Diseases
|
|---|---|
| Chapter number | 10 |
| Book title |
Drug Discovery from Mother Nature
|
| Published in |
Advances in experimental medicine and biology, October 2016
|
| DOI | 10.1007/978-3-319-41342-6_10 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-941341-9, 978-3-31-941342-6
|
| Authors |
Pharkphoom Panichayupakaranant, Md Iftekhar Ahmad |
| Editors |
Subash Chandra Gupta, Sahdeo Prasad, Bharat B. Aggarwal |
| Abstract |
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a plant-derived naphthoquinones obtained mainly from three families, including Plumbaginaceae, Droseraceae, and Ebenaceae. Plumbagin has exhibited its potential therapeutic benefits on numerous chronic diseases, i.e., breast cancer, non-small cell lung cancer, melanoma, ovarian, squamous cell carcinomas, pancreatic cancer, and prostate cancer. In addition, its anti-inflammatory and antimicrobial activities as well as control of diabetes and cardiovascular diseases have been reported. Thus, plumbagin is a promising agent for development as a new drug for the treatment or control of chronic diseases. Studies on controlled drug release or drug delivery systems have been involved for improvement of its therapeutic efficacy as well as for the reduction of its toxicity. However, most of the recent research information is from in vitro and in vivo studies. Further clinical studies are therefore required for its developments and applications as a novel drug used to treat chronic diseases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 16% |
| Student > Master | 6 | 13% |
| Student > Doctoral Student | 4 | 9% |
| Researcher | 4 | 9% |
| Student > Bachelor | 3 | 7% |
| Other | 5 | 11% |
| Unknown | 16 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 27% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Medicine and Dentistry | 2 | 4% |
| Chemistry | 2 | 4% |
| Business, Management and Accounting | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 19 | 42% |