Cancer Nanotechnology
Springer New York
Chapter title |
Nanotechnology-Based Cancer Vaccine
|
---|---|
Chapter number | 15 |
Book title |
Cancer Nanotechnology
|
Published in |
Methods in molecular biology, February 2017
|
DOI | 10.1007/978-1-4939-6646-2_15 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6644-8, 978-1-4939-6646-2
|
Authors |
Aws Alshamsan, Alshamsan, Aws |
Editors |
Reema Zeineldin |
Abstract |
Nanotechnology offers invaluable tools to tailor cancer vaccines in order to generate robust antitumor immune response. Among the types of vehicles for cancer vaccines, nanoparticles (NPs) are easier to produce with better scalability. Several nanostructures have been discussed in literature as potential delivery systems for cancer antigens. Here, we focus on polymeric NPs fabricated from poly(D,L-lactic-co-glycolic) acid (PLGA). We describe how to prepare and characterize such NPs loaded with ovalbumin (OVA) antigen and immune adjuvant monophosphoryl lipid A (MPLA). We further describe methods to test the immune efficacy of such NPs in vitro and in vivo. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Country | Count | As % |
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Unknown | 17 | 100% |
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 24% |
Student > Master | 3 | 18% |
Researcher | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Lecturer | 1 | 6% |
Other | 1 | 6% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 4 | 24% |
Immunology and Microbiology | 2 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Other | 2 | 12% |
Unknown | 6 | 35% |