| Chapter title |
Nanoparticle-Mediated X-Ray Radiation Enhancement for Cancer Therapy
|
|---|---|
| Chapter number | 25 |
| Book title |
Cancer Nanotechnology
|
| Published in |
Methods in molecular biology, February 2017
|
| DOI | 10.1007/978-1-4939-6646-2_25 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6644-8, 978-1-4939-6646-2
|
| Authors |
Autumn D. Paro, Ilanchezhian Shanmugam, Anne L. van de Ven |
| Editors |
Reema Zeineldin |
| Abstract |
Metallic nanoparticles with a high atomic number release Auger electrons in response to external beam X-ray radiation. When these nanoparticles are selectively delivered to tumors, they have the potential to locally enhance the effects of radiation therapy. Optimizing the therapeutic efficacy of these nanoparticles, however, remains a challenging and time-consuming task. Here we describe three different assays that can be used to experimentally quantify and optimize the in vitro therapeutic efficacy of nanoparticle-mediated X-ray radiation enhancement. These include an IC50 extended dose response curve, clonogenic cell survival assay, and immunoblotting. Collectively, these assays provide information about whether a given nanoparticle provides radiosensitization, the extent of the radiosensitization, and the potential mechanism of radiosensitization. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 20% |
| Student > Bachelor | 3 | 20% |
| Student > Postgraduate | 2 | 13% |
| Researcher | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 5 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 20% |
| Biochemistry, Genetics and Molecular Biology | 3 | 20% |
| Agricultural and Biological Sciences | 2 | 13% |
| Physics and Astronomy | 1 | 7% |
| Chemical Engineering | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 5 | 33% |