Chapter title |
Pulmonary Delivery of Magnetically Targeted Nano-in-Microparticles
|
---|---|
Chapter number | 23 |
Book title |
Cancer Nanotechnology
|
Published in |
Methods in molecular biology, February 2017
|
DOI | 10.1007/978-1-4939-6646-2_23 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6644-8, 978-1-4939-6646-2
|
Authors |
Amber A. McBride, Dominique N. Price, Pavan Muttil |
Editors |
Reema Zeineldin |
Abstract |
This chapter details the intratracheal delivery of dry powder microparticles termed nano-in-microparticles (NIMs) for the purpose of in vivo targeted pulmonary drug delivery. The dry powder NIMs technology improves on previous inhaled chemotherapy platforms designed as liquid formulations. Dry powder microparticles were created through the process of spray drying; a protocol detailing the formulation of NIMs dry powder is included as a separate chapter in this book. Dry powder NIMs containing fluorescent nanoparticles and magnetically-responsive superparamagnetic iron oxide nanoparticles are intratracheally delivered (insufflated) in the presence of a magnetic field and targeted to the left lung of mice. The targeting efficiency of dry powder NIMs is compared to the targeting efficiency of liquid NIMs to demonstrate the superiority of dry power targeting platforms. Targeting is assessed using fluorescence associated with NIMs detected in the mouse trachea, left lung, and right lung by an in vivo imaging system. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 50% |
Researcher | 2 | 33% |
Unknown | 1 | 17% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 17% |
Agricultural and Biological Sciences | 1 | 17% |
Physics and Astronomy | 1 | 17% |
Medicine and Dentistry | 1 | 17% |
Other | 0 | 0% |
Unknown | 1 | 17% |