Chapter title |
Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy
|
---|---|
Chapter number | 24 |
Book title |
Cancer Nanotechnology
|
Published in |
Methods in molecular biology, February 2017
|
DOI | 10.1007/978-1-4939-6646-2_24 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6644-8, 978-1-4939-6646-2
|
Authors |
Derek Hargrove, Xiuling Lu |
Editors |
Reema Zeineldin |
Abstract |
Intraperitoneal internal radiation therapy is a cancer treatment option that is employed in situations where surgical resection, systemic chemotherapy, and external beam radiotherapy are not amenable for patients. However, exposure of noncancerous tissues to radiation continues to be a hindrance to safe and effective treatment of patients. In addition, reducing prolonged radiation exposure of personnel during preparation of internal radiation therapy agents makes their manufacture complicated and hazardous. Developments in nanotechnology have provided a platform for targeted treatments that combine dual imaging and treatment capabilities all in one package, while also being robust enough to withstand the intense stresses faced during neutron activation. Here, we describe a method for synthesizing neutron activatable mesoporous silica nanoparticles for use in radiotherapy of metastatic peritoneal cancers while limiting personal exposure to radioactive materials, limiting the leakage of radioactive isotopes caused by nanoparticle degradation during neutron activation, and increasing cancer tissue specificity of radiation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Unspecified | 4 | 44% |
Student > Ph. D. Student | 2 | 22% |
Researcher | 1 | 11% |
Lecturer | 1 | 11% |
Unknown | 1 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Unspecified | 4 | 44% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 22% |
Engineering | 1 | 11% |
Unknown | 2 | 22% |