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Timeline
Mendeley readers
| Chapter title |
Modelling ChIP-seq Data Using HMMs
|
|---|---|
| Chapter number | 8 |
| Book title |
Hidden Markov Models
|
| Published in |
Methods in molecular biology, February 2017
|
| DOI | 10.1007/978-1-4939-6753-7_8 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6751-3, 978-1-4939-6753-7
|
| Authors |
Veronica Vinciotti, Vinciotti, Veronica |
| Editors |
David R. Westhead, M. S. Vijayabaskar |
| Abstract |
Chromatin ImmunoPrecipitation-sequencing (ChIP-seq) experiments have now become routine in biology for the detection of protein binding sites. In this chapter, we show how hidden Markov models can be used for the analysis of data generated by ChIP-seq experiments. We show how a hidden Markov model can naturally account for spatial dependencies in the ChIP-seq data, how it can be used in the presence of data from multiple ChIP-seq experiments under the same biological condition, and how it naturally accounts for the different IP efficiencies of individual ChIP-seq experiments. |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 100% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 1 | 100% |