Chapter title |
Annotation of Alternatively Spliced Proteins and Transcripts with Protein-Folding Algorithms and Isoform-Level Functional Networks
|
---|---|
Chapter number | 20 |
Book title |
Protein Bioinformatics
|
Published in |
Methods in molecular biology, February 2017
|
DOI | 10.1007/978-1-4939-6783-4_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6781-0, 978-1-4939-6783-4
|
Authors |
Hongdong Li, Yang Zhang, Yuanfang Guan, Rajasree Menon, Gilbert S. Omenn, Li, Hongdong, Zhang, Yang, Guan, Yuanfang, Menon, Rajasree, Omenn, Gilbert S. |
Editors |
Cathy H. Wu, Cecilia N. Arighi, Karen E. Ross |
Abstract |
Tens of thousands of splice isoforms of proteins have been catalogued as predicted sequences from transcripts in humans and other species. Relatively few have been characterized biochemically or structurally. With the extensive development of protein bioinformatics, the characterization and modeling of isoform features, isoform functions, and isoform-level networks have advanced notably. Here we present applications of the I-TASSER family of algorithms for folding and functional predictions and the IsoFunc, MIsoMine, and Hisonet data resources for isoform-level analyses of network and pathway-based functional predictions and protein-protein interactions. Hopefully, predictions and insights from protein bioinformatics will stimulate many experimental validation studies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 30% |
Student > Master | 2 | 10% |
Other | 2 | 10% |
Student > Doctoral Student | 2 | 10% |
Student > Ph. D. Student | 2 | 10% |
Other | 5 | 25% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 35% |
Computer Science | 4 | 20% |
Engineering | 2 | 10% |
Medicine and Dentistry | 2 | 10% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 15% |