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Mammary Gland Development

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Cover of 'Mammary Gland Development'

Table of Contents

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    Book Overview
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    Chapter 1 Overview of Mammary Gland Development: A Comparison of Mouse and Human.
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    Chapter 2 Prenatal Mammary Gland Development in the Mouse: Research Models and Techniques for Its Study from Past to Present.
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    Chapter 3 Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models.
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    Chapter 4 Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium.
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    Chapter 5 Mammary Gland Development
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    Chapter 6 Mammary Gland Development
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    Chapter 7 Analysis of the Involuting Mouse Mammary Gland: An In Vivo Model for Cell Death.
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    Chapter 8 Contractility Assay for Established Myoepithelial Cell Lines.
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    Chapter 9 Using 3D Culture of Primary Mammary Epithelial Cells to Define Molecular Entities Required for Acinus Formation: Analyzing MAP Kinase Phosphatases.
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    Chapter 10 A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland.
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    Chapter 11 Next Generation RNA Sequencing Analysis Reveals Expression of a Transient EMT Profile During Early Organization of MCF10A Cells in 3D.
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    Chapter 12 A 3D Culture Model to Study How Fluid Pressure and Flow Affect the Behavior of Aggregates of Epithelial Cells.
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    Chapter 13 Purification of Distinct Subsets of Epithelial Cells from Normal Human Breast Tissue.
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    Chapter 14 Techniques for the Reprogramming of Exogenous Stem/Progenitor Cell Populations Towards a Mammary Epithelial Cell Fate.
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    Chapter 15 Lineage Tracing of Mammary Stem and Progenitor Cells.
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    Chapter 16 Assessment of Significance of Novel Proteins in Breast Cancer Using Tissue Microarray Technology.
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    Chapter 17 Patient-Derived Xenografts of Breast Cancer.
Attention for Chapter 10: A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland.
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Chapter title
A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland.
Chapter number 10
Book title
Mammary Gland Development
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6475-8_10
Pubmed ID
Book ISBNs
978-1-4939-6473-4, 978-1-4939-6475-8
Authors

Zuzana Koledova, Pengfei Lu

Editors

Finian Martin, Torsten Stein, Jillian Howlin

Abstract

The mammary gland consists of numerous tissue compartments, including mammary epithelium, an array of stromal cells, and the extracellular matrix (ECM). Bidirectional interactions between the epithelium and its surrounding stroma are essential for proper mammary gland development and homeostasis, whereas their deregulation leads to developmental abnormalities and cancer. To study the relationships between the epithelium and the stroma, development of models that could recapitulate essential aspects of these interacting systems in vitro has become necessary. Here we describe a three-dimensional (3D) co-culture assay and show that the addition of fibroblasts to mammary organoid cultures promotes the epithelium to undergo branching morphogenesis, thus allowing the role of the stromal microenvironment to be examined in this essential developmental process.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 15%
Student > Ph. D. Student 4 12%
Student > Doctoral Student 3 9%
Other 3 9%
Student > Bachelor 2 6%
Other 5 15%
Unknown 11 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 21%
Medicine and Dentistry 4 12%
Agricultural and Biological Sciences 3 9%
Chemical Engineering 2 6%
Engineering 2 6%
Other 3 9%
Unknown 12 36%