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Mammary Gland Development

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Cover of 'Mammary Gland Development'

Table of Contents

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    Book Overview
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    Chapter 1 Overview of Mammary Gland Development: A Comparison of Mouse and Human.
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    Chapter 2 Prenatal Mammary Gland Development in the Mouse: Research Models and Techniques for Its Study from Past to Present.
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    Chapter 3 Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models.
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    Chapter 4 Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium.
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    Chapter 5 Mammary Gland Development
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    Chapter 6 Mammary Gland Development
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    Chapter 7 Analysis of the Involuting Mouse Mammary Gland: An In Vivo Model for Cell Death.
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    Chapter 8 Contractility Assay for Established Myoepithelial Cell Lines.
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    Chapter 9 Using 3D Culture of Primary Mammary Epithelial Cells to Define Molecular Entities Required for Acinus Formation: Analyzing MAP Kinase Phosphatases.
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    Chapter 10 A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland.
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    Chapter 11 Next Generation RNA Sequencing Analysis Reveals Expression of a Transient EMT Profile During Early Organization of MCF10A Cells in 3D.
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    Chapter 12 A 3D Culture Model to Study How Fluid Pressure and Flow Affect the Behavior of Aggregates of Epithelial Cells.
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    Chapter 13 Purification of Distinct Subsets of Epithelial Cells from Normal Human Breast Tissue.
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    Chapter 14 Techniques for the Reprogramming of Exogenous Stem/Progenitor Cell Populations Towards a Mammary Epithelial Cell Fate.
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    Chapter 15 Lineage Tracing of Mammary Stem and Progenitor Cells.
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    Chapter 16 Assessment of Significance of Novel Proteins in Breast Cancer Using Tissue Microarray Technology.
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    Chapter 17 Patient-Derived Xenografts of Breast Cancer.
Attention for Chapter 2: Prenatal Mammary Gland Development in the Mouse: Research Models and Techniques for Its Study from Past to Present.
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Chapter title
Prenatal Mammary Gland Development in the Mouse: Research Models and Techniques for Its Study from Past to Present.
Chapter number 2
Book title
Mammary Gland Development
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6475-8_2
Pubmed ID
Book ISBNs
978-1-4939-6473-4, 978-1-4939-6475-8

Jacqueline M. Veltmaat Ph.D., Jacqueline M. Veltmaat


Finian Martin, Torsten Stein, Jillian Howlin


Mammary gland development starts during prenatal life, when at designated positions along the ventrolateral boundary of the embryonic or fetal trunk, surface ectodermal cells coalesce to form primordia for mammary glands, instead of differentiating into epidermis. With the wealth of genetically engineered mice available as research models, our understanding of the prenatal phase of mammary development has recently greatly advanced. This understanding includes the recognition of molecular and mechanistic parallels between prenatal and postnatal mammary morphogenesis and even tumorigenesis, much of which can moreover be extrapolated to human. This makes the murine embryonic mammary gland a useful model for a myriad of questions pertaining to normal and pathological breast development. Hence, unless indicated otherwise, this review describes embryonic mammary gland development in mouse only, and lists mouse models that have been examined for defects in embryonic mammary development. Techniques that originated in the field of developmental biology, such as explant culture and tissue recombination, were adapted specifically to research on the embryonic mammary gland. Detailed protocols for these techniques have recently been published elsewhere. This review describes how the development and adaptation of these techniques moved the field forward from insights on (comparative) morphogenesis of the embryonic mammary gland to the understanding of tissue and molecular interactions and their regulation of morphogenesis and functional development of the embryonic mammary gland. It is here furthermore illustrated how generic molecular biology and biochemistry techniques can be combined with these older, developmental biology techniques, to address relevant research questions. As such, this review should provide a solid starting point for those wishing to familiarize themselves with this fascinating and important subdomain of mammary gland biology, and guide them in designing a relevant research strategy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 29%
Unspecified 2 14%
Student > Ph. D. Student 2 14%
Student > Doctoral Student 1 7%
Other 1 7%
Other 1 7%
Unknown 3 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 21%
Unspecified 2 14%
Nursing and Health Professions 2 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 7%
Veterinary Science and Veterinary Medicine 1 7%
Other 2 14%
Unknown 3 21%