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Mammary Gland Development

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Cover of 'Mammary Gland Development'

Table of Contents

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    Book Overview
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    Chapter 1 Overview of Mammary Gland Development: A Comparison of Mouse and Human.
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    Chapter 2 Prenatal Mammary Gland Development in the Mouse: Research Models and Techniques for Its Study from Past to Present.
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    Chapter 3 Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models.
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    Chapter 4 Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium.
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    Chapter 5 Mammary Gland Development
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    Chapter 6 Mammary Gland Development
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    Chapter 7 Analysis of the Involuting Mouse Mammary Gland: An In Vivo Model for Cell Death.
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    Chapter 8 Contractility Assay for Established Myoepithelial Cell Lines.
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    Chapter 9 Using 3D Culture of Primary Mammary Epithelial Cells to Define Molecular Entities Required for Acinus Formation: Analyzing MAP Kinase Phosphatases.
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    Chapter 10 A 3D Fibroblast-Epithelium Co-culture Model for Understanding Microenvironmental Role in Branching Morphogenesis of the Mammary Gland.
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    Chapter 11 Next Generation RNA Sequencing Analysis Reveals Expression of a Transient EMT Profile During Early Organization of MCF10A Cells in 3D.
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    Chapter 12 A 3D Culture Model to Study How Fluid Pressure and Flow Affect the Behavior of Aggregates of Epithelial Cells.
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    Chapter 13 Purification of Distinct Subsets of Epithelial Cells from Normal Human Breast Tissue.
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    Chapter 14 Techniques for the Reprogramming of Exogenous Stem/Progenitor Cell Populations Towards a Mammary Epithelial Cell Fate.
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    Chapter 15 Lineage Tracing of Mammary Stem and Progenitor Cells.
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    Chapter 16 Assessment of Significance of Novel Proteins in Breast Cancer Using Tissue Microarray Technology.
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    Chapter 17 Patient-Derived Xenografts of Breast Cancer.
Attention for Chapter 3: Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models.
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Chapter title
Pubertal Mammary Gland Development: Elucidation of In Vivo Morphogenesis Using Murine Models.
Chapter number 3
Book title
Mammary Gland Development
Published in
Methods in molecular biology, January 2017
DOI 10.1007/978-1-4939-6475-8_3
Pubmed ID
Book ISBNs
978-1-4939-6473-4, 978-1-4939-6475-8

Jean McBryan, Jillian Howlin Ph.D., Jillian Howlin


Finian Martin, Torsten Stein, Jillian Howlin


During the past 25 years, the combination of increasingly sophisticated gene targeting technology with transplantation techniques has allowed researchers to address a wide array of questions about postnatal mammary gland development. These in turn have significantly contributed to our knowledge of other branched epithelial structures. This review chapter highlights a selection of the mouse models exhibiting a pubertal mammary gland phenotype with a focus on how they have contributed to our overall understanding of in vivo mammary morphogenesis. We discuss mouse models that have enabled us to assign functions to particular genes and proteins and, more importantly, have determined when and where these factors are required for completion of ductal outgrowth and branch patterning. The reason for the success of the mouse mammary gland model is undoubtedly the suitability of the postnatal mammary gland to experimental manipulation. The gland itself is very amenable to investigation and the combination of genetic modification with accessibility to the tissue has allowed an impressive number of studies to inform biology. Excision of the rudimentary epithelial structure postnatally allows genetically modified tissue to be readily transplanted into wild type stroma or vice versa, and has thus defined the contribution of each compartment to particular phenotypes. Similarly, whole gland transplantation has been used to definitively discern local effects from indirect systemic effects of various growth factors and hormones. While appreciative of the power of these tools and techniques, we are also cognizant of some of their limitations, and we discuss some shortcomings and future strategies that can overcome them.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 22%
Student > Doctoral Student 4 17%
Unspecified 2 9%
Student > Bachelor 2 9%
Other 1 4%
Other 2 9%
Unknown 7 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 22%
Agricultural and Biological Sciences 3 13%
Unspecified 2 9%
Environmental Science 1 4%
Nursing and Health Professions 1 4%
Other 3 13%
Unknown 8 35%