| Chapter title |
Chromosome Architecture
|
|---|---|
| Chapter number | 9 |
| Book title |
Chromosome Architecture
|
| Published in |
Methods in molecular biology, January 2016
|
| DOI | 10.1007/978-1-4939-3631-1_9 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3629-8, 978-1-4939-3631-1
|
| Authors |
Sewitz, Sven, Lipkow, Karen, Sven Sewitz, Karen Lipkow |
| Editors |
Mark C. Leake |
| Abstract |
The linear and three-dimensional arrangement and composition of chromatin in eukaryotic genomes underlies the mechanisms directing gene regulation. Understanding this organization requires the integration of many data types and experimental results. Here we describe the approach of integrating genome-wide protein-DNA binding data to determine chromatin states. To investigate spatial aspects of genome organization, we present a detailed description of how to run stochastic simulations of protein movements within a simulated nucleus in 3D. This systems level approach enables the development of novel questions aimed at understanding the basic mechanisms that regulate genome dynamics. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 57% |
| Researcher | 1 | 14% |
| Lecturer > Senior Lecturer | 1 | 14% |
| Student > Master | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
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| Neuroscience | 2 | 29% |
| Physics and Astronomy | 1 | 14% |
| Agricultural and Biological Sciences | 1 | 14% |