You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Chapter title |
Delivery of the Porcupine Inhibitor WNT974 in Mice.
|
---|---|
Chapter number | 12 |
Book title |
Wnt Signaling
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-6393-5_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6391-1, 978-1-4939-6393-5
|
Authors |
Li-shu Zhang, Lawrence Lum |
Editors |
Quinn Barrett, Lawrence Lum |
Abstract |
We describe here a technique for delivering the porcupine inhibitor WNT974 (formerly LGK974) in mice. The protocol entails once-a-day oral delivery of WNT974 for up to 3 months at a concentration sufficient to achieve systemic Wnt pathway inhibition with limited toxicity as measured by weight change. This route of delivery enables extended durations of Wnt signaling inhibition in a mammalian model organism. |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 9% |
Unknown | 10 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 27% |
Researcher | 3 | 27% |
Student > Ph. D. Student | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Student > Postgraduate | 1 | 9% |
Other | 0 | 0% |
Unknown | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 45% |
Biochemistry, Genetics and Molecular Biology | 3 | 27% |
Agricultural and Biological Sciences | 2 | 18% |
Physics and Astronomy | 1 | 9% |