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Chapter title |
Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway
|
---|---|
Chapter number | 6 |
Book title |
High-Throughput Screening Assays in Toxicology
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Published in |
Methods in molecular biology, January 2016
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DOI | 10.1007/978-1-4939-6346-1_6 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6344-7, 978-1-4939-6346-1
|
Authors |
Jinghua Zhao, Sunita J. Shukla, Menghang Xia, Zhao, Jinghua, Shukla, Sunita J., Xia, Menghang |
Abstract |
The antioxidant response element (ARE) signaling pathway plays an important role in the amelioration of cellular oxidative stress. Thus, assays that detect this pathway can be useful for identifying chemicals that induce or inhibit oxidative stress signaling. The focus of this chapter is to describe a cell-based ARE assay in a quantitative high-throughput screening (qHTS) format to test a large collection of compounds that induce nuclear factor erythroid 2-related factor (Nrf2)/ARE signaling. The assay is described through cell handling, assay preparation, and instrument usage. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 29% |
Student > Bachelor | 1 | 14% |
Unknown | 4 | 57% |
Readers by discipline | Count | As % |
---|---|---|
Chemical Engineering | 1 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 14% |
Neuroscience | 1 | 14% |
Unknown | 4 | 57% |