Chapter title |
A Framework for Discovering, Designing, and Testing MicroProteins to Regulate Synthetic Transcriptional Modules
|
---|---|
Chapter number | 12 |
Book title |
Plant Synthetic Promoters
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-6396-6_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6394-2, 978-1-4939-6396-6
|
Authors |
Elisa Fiume, Niek de Klein, Seung Yon Rhee, Enrico Magnani, Fiume, Elisa, de Klein, Niek, Rhee, Seung Yon, Magnani, Enrico |
Editors |
Reinhard Hehl |
Abstract |
Transcription factors often form protein complexes and give rise to intricate transcriptional networks. The regulation of transcription factor multimerization plays a key role in the fine-tuning of the underlying transcriptional pathways and can be exploited to modulate synthetic transcriptional modules. A novel regulation of protein complex formation is emerging: microProteins-truncated transcription factors-engage in protein-protein interactions with transcriptional complexes and modulate their transcriptional activity. Here, we outline a strategy for the discovery, design, and test of putative miPs to fine-tune the activity of transcription factors regulating synthetic or natural transcriptional circuits. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 30% |
Researcher | 3 | 30% |
Student > Ph. D. Student | 1 | 10% |
Student > Bachelor | 1 | 10% |
Unknown | 2 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 3 | 30% |
Biochemistry, Genetics and Molecular Biology | 2 | 20% |
Medicine and Dentistry | 1 | 10% |
Unknown | 4 | 40% |