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The Alkali Metal Ions: Their Role for Life

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Cover of 'The Alkali Metal Ions: Their Role for Life'

Table of Contents

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    Book Overview
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    Chapter 1 Bioinorganic Chemistry of the Alkali Metal Ions
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    Chapter 2 The Alkali Metal Ions: Their Role for Life
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    Chapter 3 The Alkali Metal Ions: Their Role for Life
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    Chapter 4 Discriminating Properties of Alkali Metal Ions Towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies
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    Chapter 5 Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution
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    Chapter 6 Sodium and Potassium Interactions with Nucleic Acids
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    Chapter 7 Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability
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    Chapter 8 Sodium and Potassium Ions in Proteins and Enzyme Catalysis
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    Chapter 9 Roles and Transport of Sodium and Potassium in Plants.
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    Chapter 10 Potassium Versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters
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    Chapter 11 Sodium as Coupling Cation in Respiratory Energy Conversion
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    Chapter 12 The Alkali Metal Ions: Their Role for Life
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    Chapter 13 Proton-Potassium (H + /K + ) ATPases: Properties and Roles in Health and Diseases
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    Chapter 14 Bioinspired Artificial Sodium and Potassium Ion Channels
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    Chapter 15 The Alkali Metal Ions: Their Role for Life
  17. Altmetric Badge
    Chapter 16 Sodium and Potassium Relating to Parkinson’s Disease and Traumatic Brain Injury
Attention for Chapter 5: Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution
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Chapter title
Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution
Chapter number 5
Book title
The Alkali Metal Ions: Their Role for Life
Published in
Metal ions in life sciences, January 2016
DOI 10.1007/978-3-319-21756-7_5
Pubmed ID
Book ISBNs
978-3-31-921755-0, 978-3-31-921756-7
Authors

Francesco Crea, Concetta De Stefano, Claudia Foti, Gabriele Lando, Demetrio Milea, Silvio Sammartano, Crea, Francesco, De Stefano, Concetta, Foti, Claudia, Lando, Gabriele, Milea, Demetrio, Sammartano, Silvio

Abstract

Alkali metal ions play very important roles in all biological systems, some of them are essential for life. Their concentration depends on several physiological factors and is very variable. For example, sodium concentrations in human fluids vary from quite low (e.g., 8.2 mmol dm(-3) in mature maternal milk) to high values (0.14 mol dm(-3) in blood plasma). While many data on the concentration of Na(+) and K(+) in various fluids are available, the information on other alkali metal cations is scarce. Since many vital functions depend on the network of interactions occurring in various biofluids, this chapter reviews their complex formation with phosphates, nucleotides, amino acids, and related ligands of biological relevance. Literature data on this topic are quite rare if compared to other cations. Generally, the stability of alkali metal ion complexes of organic and inorganic ligands is rather low (usually log K < 2) and depends on the charge of the ligand, owing to the ionic nature of the interactions. At the same time, the size of the cation is an important factor that influences the stability: very often, but not always (e.g., for sulfate), it follows the trend Li(+) > Na(+) > K(+) > Rb(+) > Cs(+). For example, for citrate it is: log K ML = 0.88, 0.80, 0.48, 0.38, and 0.13 at 25 °C and infinite dilution. Some considerations are made on the main aspects related to the difficulties in the determination of weak complexes. The importance of the alkali metal ion complexes was also studied in the light of modelling natural fluids and in the use of these cations as probes for different processes. Some empirical relationships are proposed for the dependence of the stability constants of Na(+) complexes on the ligand charge, as well as for correlations among log K values of NaL, KL or LiL species (L = generic ligand).

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 25%
Student > Ph. D. Student 3 25%
Other 2 17%
Professor > Associate Professor 2 17%
Unspecified 1 8%
Other 0 0%
Unknown 1 8%
Readers by discipline Count As %
Chemistry 6 50%
Agricultural and Biological Sciences 2 17%
Unspecified 1 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Unknown 2 17%