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The Alkali Metal Ions: Their Role for Life

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Cover of 'The Alkali Metal Ions: Their Role for Life'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Bioinorganic Chemistry of the Alkali Metal Ions
  3. Altmetric Badge
    Chapter 2 The Alkali Metal Ions: Their Role for Life
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    Chapter 3 The Alkali Metal Ions: Their Role for Life
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    Chapter 4 Discriminating Properties of Alkali Metal Ions Towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies
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    Chapter 5 Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution
  7. Altmetric Badge
    Chapter 6 Sodium and Potassium Interactions with Nucleic Acids
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    Chapter 7 Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability
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    Chapter 8 Sodium and Potassium Ions in Proteins and Enzyme Catalysis
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    Chapter 9 Roles and Transport of Sodium and Potassium in Plants.
  11. Altmetric Badge
    Chapter 10 Potassium Versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters
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    Chapter 11 Sodium as Coupling Cation in Respiratory Energy Conversion
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    Chapter 12 The Alkali Metal Ions: Their Role for Life
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    Chapter 13 Proton-Potassium (H + /K + ) ATPases: Properties and Roles in Health and Diseases
  15. Altmetric Badge
    Chapter 14 Bioinspired Artificial Sodium and Potassium Ion Channels
  16. Altmetric Badge
    Chapter 15 The Alkali Metal Ions: Their Role for Life
  17. Altmetric Badge
    Chapter 16 Sodium and Potassium Relating to Parkinson’s Disease and Traumatic Brain Injury
Attention for Chapter 12: The Alkali Metal Ions: Their Role for Life
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About this Attention Score

  • Among the highest-scoring outputs from this source (#46 of 133)
  • Above-average Attention Score compared to outputs of the same age (54th percentile)

Mentioned by

wikipedia
4 Wikipedia pages

Citations

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43 Dimensions

Readers on

mendeley
63 Mendeley
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Chapter title
The Alkali Metal Ions: Their Role for Life
Chapter number 12
Book title
The Alkali Metal Ions: Their Role for Life
Published in
Metal ions in life sciences, October 2016
DOI 10.1007/978-3-319-21756-7_12
Pubmed ID
Book ISBNs
978-3-31-921755-0, 978-3-31-921756-7
Authors

Etana Padan, Meytal Landau, Padan, Etana, Landau, Meytal

Abstract

The transmembranal Na(+)/H(+) antiporters transport sodium (or several other monovalent cations) in exchange for H(+) across lipid bilayers in all kingdoms of life. They are critical in pH homeostasis of the cytoplasm and/or organelles. A particularly notable example is the SLC9 gene family, which encodes Na(+)/H(+) exchangers (NHEs) in many species from prokaryotes to eukaryotes. In humans, these proteins are associated with the pathophysiology of various diseases. Yet, the most extensively studied Na(+)/H(+) antiporter is Ec-NhaA, the main Na(+)/H(+) antiporter of Escherichia coli.The crystal structure of down-regulated Ec-NhaA, determined at acidic pH, has provided the first structural insights into the antiport mechanism and pH regulation of an Na(+)/H(+) antiporter. It reveals a unique structural fold (called the NhaA fold) in which transmembrane segments (TMs) are organized in inverted-topology repeats, including two antiparallel unfolded regions that cross each other, forming a delicate electrostatic balance in the middle of the membrane. This unique structural fold (The NhaA fold) contributes to the cation binding site and facilitates the rapid conformational changes expected for Ec-NhaA. The NhaA fold has now been recognized to be shared by four Na(+)/H(+) antiporters (bacterial and archaeal) and a Na(+) symporter. Remarkably, no crystal structure of any of the human Na(+)/H(+) antiporters exists. Nevertheless, the Ec-NhaA crystal structure has enabled the structural modeling of NHE1, NHE9, and NHA2, three human plasmalemmal proteins that are members of the SLC9 family that are involved in human pathophysiology. Moreover, as outlined in this review, developments in the field, including cellular and biophysical methods that enable ion levels and fluxes to be measured in intact cells as well as in knockout mice, have led to striking advances in the identification and characterization of plasma membrane NHEs and NHA.Very little is known about the endomembrane isoforms of NHE. These intracellular exchangers may serve a function in cation homeostasis and/or osmoregulation, and not in pH regulation as is the case for the plasmalemmal isoforms. This intriguing possibility should be borne in mind when designing future studiesFuture progress towards gaining an understanding of the SLC9 gene family, including its structure-function relationships and regulatory mechanisms in health and in disease, is likely to include insights into the pathophysiology of multiple diseases.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 29%
Student > Master 11 17%
Student > Bachelor 7 11%
Researcher 5 8%
Other 3 5%
Other 10 16%
Unknown 9 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 35%
Chemistry 9 14%
Agricultural and Biological Sciences 7 11%
Engineering 4 6%
Medicine and Dentistry 3 5%
Other 7 11%
Unknown 11 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2022.
All research outputs
#7,188,608
of 22,060,496 outputs
Outputs from Metal ions in life sciences
#46
of 133 outputs
Outputs of similar age
#106,845
of 294,652 outputs
Outputs of similar age from Metal ions in life sciences
#1
of 1 outputs
Altmetric has tracked 22,060,496 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 133 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,652 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them