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The Alkali Metal Ions: Their Role for Life

Overview of attention for book
Cover of 'The Alkali Metal Ions: Their Role for Life'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Bioinorganic Chemistry of the Alkali Metal Ions
  3. Altmetric Badge
    Chapter 2 The Alkali Metal Ions: Their Role for Life
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    Chapter 3 The Alkali Metal Ions: Their Role for Life
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    Chapter 4 Discriminating Properties of Alkali Metal Ions Towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies
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    Chapter 5 Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution
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    Chapter 6 Sodium and Potassium Interactions with Nucleic Acids
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    Chapter 7 Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability
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    Chapter 8 Sodium and Potassium Ions in Proteins and Enzyme Catalysis
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    Chapter 9 Roles and Transport of Sodium and Potassium in Plants.
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    Chapter 10 Potassium Versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters
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    Chapter 11 Sodium as Coupling Cation in Respiratory Energy Conversion
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    Chapter 12 The Alkali Metal Ions: Their Role for Life
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    Chapter 13 Proton-Potassium (H + /K + ) ATPases: Properties and Roles in Health and Diseases
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    Chapter 14 Bioinspired Artificial Sodium and Potassium Ion Channels
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    Chapter 15 The Alkali Metal Ions: Their Role for Life
  17. Altmetric Badge
    Chapter 16 Sodium and Potassium Relating to Parkinson’s Disease and Traumatic Brain Injury
Attention for Chapter 10: Potassium Versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters
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About this Attention Score

  • Among the highest-scoring outputs from this source (#36 of 116)
  • Above-average Attention Score compared to outputs of the same age (58th percentile)

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Chapter title
Potassium Versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters
Chapter number 10
Book title
The Alkali Metal Ions: Their Role for Life
Published in
Metal ions in life sciences, January 2016
DOI 10.1007/978-3-319-21756-7_10
Pubmed ID
Book ISBNs
978-3-31-921755-0, 978-3-31-921756-7

Carmay Lim, Todor Dudev, Lim, Carmay, Dudev, Todor


Transport of Na(+) and K(+) ions across the cell membrane is carried out by specialized pore-forming ion channel proteins, which exert tight control on electrical signals in cells by regulating the inward/outward flow of the respective cation. As Na(+) and K(+) ions are both present in the body fluids, their respective ion channels should discriminate with high fidelity between the two competing metal ions, conducting the native cation while rejecting its monovalent contender (and other ions present in the cellular/extracellular milieu). Indeed, monovalent ion channels are characterized by remarkable metal selectivity. This striking ion selectivity of monovalent ion channels is astonishing in view of the close similarity between Na(+) and K(+): both are spherical alkali cations with the same charge, analogous chemical and physical properties, and similar ionic radii. The monovalent ion channel selectivity filters (SFs), which dictate the selectivity of the channel, differ in oligomericity, composition, overall charge, pore size, and solvent accessibility. This diversity of SFs raises the following intriguing questions: (1) What factors govern the metal competition in these SFs? (2) Which of these factors are exploited in achieving K(+) or Na(+) selectivity in the different types of monovalent channel SFs? These questions are addressed herein by summarizing results from recent studies. The results show that over billions of years of evolution, the SFs of potassium and sodium ion channels have adapted to the specific physicochemical properties of the cognate ion, using various strategies to enable them to efficiently select the native ion among its contenders.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 20%
Student > Bachelor 2 13%
Student > Ph. D. Student 2 13%
Professor 2 13%
Lecturer > Senior Lecturer 1 7%
Other 2 13%
Unknown 3 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 20%
Chemistry 3 20%
Medicine and Dentistry 2 13%
Physics and Astronomy 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Other 2 13%
Unknown 3 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2020.
All research outputs
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Outputs from Metal ions in life sciences
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Outputs of similar age
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Outputs of similar age from Metal ions in life sciences
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Altmetric has tracked 17,100,199 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 116 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,134 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them