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New Psychoactive Substances

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Cover of 'New Psychoactive Substances'

Table of Contents

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    Book Overview
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    Chapter 83 Bioanalytical Methods for New Psychoactive Substances
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    Chapter 102 Toxicokinetics of NPS: Update 2017
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    Chapter 107 Serotonergic Psychedelics: Experimental Approaches for Assessing Mechanisms of Action
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    Chapter 110 Fatal Poisonings Associated with New Psychoactive Substances
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    Chapter 111 Wastewater Analysis for Community-Wide Drugs Use Assessment
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    Chapter 113 Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances
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    Chapter 124 Phencyclidine-Based New Psychoactive Substances
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    Chapter 127 Emergence, Diversity, and Control of New Psychoactive Substances: A Global Perspective
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    Chapter 134 Epidemiology of NPS Based Confirmed Overdose Cases: The STRIDA Project
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    Chapter 135 Patterns of Acute Toxicity Associated with New Psychoactive Substances
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    Chapter 143 The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substances: Origins
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    Chapter 144 The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution
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    Chapter 148 1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances
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    Chapter 149 Synthetic Opioids
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    Chapter 154 Designer Benzodiazepines: Another Class of New Psychoactive Substances
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    Chapter 160 Responding to New Psychoactive Substances in the European Union: Early Warning, Risk Assessment, and Control Measures
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    Chapter 177 Self-Experiments with Psychoactive Substances: A Historical Perspective
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    Chapter 178 Neuropharmacology of Synthetic Cathinones
Attention for Chapter 148: 1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

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8 Wikipedia pages


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Chapter title
1,2-Diarylethylamine- and Ketamine-Based New Psychoactive Substances
Chapter number 148
Book title
New Psychoactive Substances
Published in
Handbook of experimental pharmacology, September 2018
DOI 10.1007/164_2018_148
Pubmed ID
Book ISBNs
978-3-03-010560-0, 978-3-03-010561-7

Jason Wallach, Simon D. Brandt, Wallach, Jason, Brandt, Simon D.


While phencyclidine (PCP) and ketamine remain the most well-studied and widely known dissociative drugs, a number of other agents have appeared since the late 1950s and early 1960s, when the pharmacological potential of this class was first realized. For example, hundreds of compounds have been pursued as part of legitimate research efforts to explore these agents. Some of these found their way out of the research labs and onto illicit markets of the 1960s and following decades as PCP analogs. Other "illicit analogs" apparently never appeared in the scientific literature prior to their existence on clandestine markets, thus originating as novel innovations in the minds of clandestine chemists and their colleagues. Like so much else in this world, new technologies changed this dynamic. In the 1990s individuals separated by vast geographical distances could now communicate nearly instantaneously with ease through the Internet. Some individuals used this newly found opportunity to discuss the chemistry and psychoactive effects of dissociative drugs as well as to collaborate on the design and development of novel dissociative compounds. Similar to modern pharmaceutical companies and academic researchers, these seekers tinkered with the structure of their leads pursuing goals such as improved duration of action, analgesic effects, and reduced toxicity. Whether all these goals were achieved for any individual compound remains to be seen, but their creations have been let out of the bag and are now materialized as defined compositions of matter. Moreover, these creations now exist not only in and of themselves but live on further as permutations into various novel analogs and derivatives. In some cases these compounds have made their way to academic labs where potential clinical applications have been identified. These compounds reached wider distribution when other individuals picked up on these discussions and began to market them as "research chemicals" or "legal highs". The result is a continuously evolving game that is being played between legislatures, law enforcement, and research chemical market players. Two structurally distinct classes that have appeared as dissociative-based new psychoactive substances (NPS) are the 1,2-diarylethylamines and β-keto-arylcyclohexylamines. Examples of the former include diphenidine and various analogs such as fluorolintane and N-ethyl-lanicemine, and examples of the latter are analogs of ketamine such as methoxetamine, deschloroketamine, and 2-fluoro-2-deschloroketamine. The subject of this chapter is the introduction to some of the dissociative NPS from these classes and their known pharmacology that have emerged on the market in recent years.

X Demographics

X Demographics

The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 8 13%
Student > Ph. D. Student 8 13%
Researcher 8 13%
Student > Bachelor 8 13%
Student > Master 5 8%
Other 3 5%
Unknown 20 33%
Readers by discipline Count As %
Medicine and Dentistry 11 18%
Chemistry 5 8%
Psychology 5 8%
Immunology and Microbiology 2 3%
Neuroscience 2 3%
Other 9 15%
Unknown 26 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2023.
All research outputs
of 23,567,572 outputs
Outputs from Handbook of experimental pharmacology
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Outputs of similar age
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Outputs of similar age from Handbook of experimental pharmacology
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Altmetric has tracked 23,567,572 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 654 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,643 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.