| Chapter title |
Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury
|
|---|---|
| Chapter number | 3 |
| Book title |
Human Neural Stem Cells
|
| Published in |
Results and problems in cell differentiation, January 2018
|
| DOI | 10.1007/978-3-319-93485-3_3 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-993484-6, 978-3-31-993485-3
|
| Authors |
Pavla Jendelova, Eva Sykova, Slaven Erceg, Jendelova, Pavla, Sykova, Eva, Erceg, Slaven |
| Abstract |
Induced pluripotent stem (iPS) cells are derived from differentiated cells by different reprogramming techniques, by introducing specific transcription factors responsible for pluripotency. Induced pluripotent stem cells can serve as an excellent source for differentiated neural stem/progenitor cells (NSCs/NPs). Several methods and protocols are utilized to create a robust number of NSCs/NPs without jeopardizing the safety issues required for in vivo applications. A variety of disease-specific iPS cells have been used to study nervous system diseases. In this chapter, we will focus on some of the derivation and differentiation approaches and the application of iPS-NPs in the treatment of spinal cord injury and stroke. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 24% |
| Student > Master | 4 | 16% |
| Student > Ph. D. Student | 3 | 12% |
| Professor | 1 | 4% |
| Unspecified | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 10 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 20% |
| Biochemistry, Genetics and Molecular Biology | 4 | 16% |
| Medicine and Dentistry | 2 | 8% |
| Agricultural and Biological Sciences | 2 | 8% |
| Unspecified | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 11 | 44% |