Chapter title |
Fc Glyco- and Fc Protein-Engineering: Design of Antibody Variants with Improved ADCC and CDC Activity
|
---|---|
Chapter number | 20 |
Book title |
Antibody Engineering
|
Published in |
Methods in molecular biology, September 2018
|
DOI | 10.1007/978-1-4939-8648-4_20 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8647-7, 978-1-4939-8648-4
|
Authors |
Christian Kellner, Stefanie Derer, Katja Klausz, Sophia Rosskopf, Tim Wirt, Thies Rösner, Anna Otte, Elisa Cappuzzello, Matthias Peipp, Kellner, Christian, Derer, Stefanie, Klausz, Katja, Rosskopf, Sophia, Wirt, Tim, Rösner, Thies, Otte, Anna, Cappuzzello, Elisa, Peipp, Matthias |
Abstract |
Monoclonal antibodies are established treatment options in cancer therapy. However, not all patients benefit from antibody therapy. Basic research and findings from clinical trials revealed that certain Fc-mediated effector mechanisms triggered by monoclonal antibodies are essential for efficient antitumor activity. Today, next-generation monoclonal antibodies can be designed displaying tailor-made improved effector functions. The introduction of Fc-engineering technologies offers the potential to fine-tune Fc-mediated effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, or complement-dependent cytotoxicity (CDC). Fc-engineered antibodies hopefully will overcome some limitations of current forms of antibody therapy. |
X Demographics
Geographical breakdown
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 24% |
Student > Bachelor | 4 | 16% |
Student > Master | 4 | 16% |
Student > Ph. D. Student | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 3 | 12% |
Unknown | 4 | 16% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 20% |
Immunology and Microbiology | 5 | 20% |
Agricultural and Biological Sciences | 4 | 16% |
Medicine and Dentistry | 3 | 12% |
Unspecified | 1 | 4% |
Other | 2 | 8% |
Unknown | 5 | 20% |