Chapter title |
Effects of Dietary Nutrients on Epigenetic Changes in Cancer
|
---|---|
Chapter number | 7 |
Book title |
Cancer Epigenetics for Precision Medicine
|
Published in |
Methods in molecular biology, September 2018
|
DOI | 10.1007/978-1-4939-8751-1_7 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8750-4, 978-1-4939-8751-1
|
Authors |
Nicoleta Andreescu, Maria Puiu, Mihai Niculescu, Andreescu, Nicoleta, Puiu, Maria, Niculescu, Mihai |
Abstract |
Gene-nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to disease, including cancer, through epigenetic changes. Nutrients can influence the epigenetic status through several mechanisms, such as DNA methylation, histone modifications, and miRNA-dependent gene silencing. These alterations were associated with either increased or decreased risk for cancer development. There is convincing evidence indicating that several foods have protective roles in cancer prevention, by inhibiting tumor progression directly or through modifying tumor's microenvironment that leads to hostile conditions favorable to tumor initiation or growth. While nutritional intakes from foods cannot be adequately controlled for dosage, the role of nutrients in the epigenetics of cancer has led to more research aimed at developing nutriceuticals and drugs as cancer therapies. Clinical studies are needed to evaluate the optimum doses of dietary compounds, the safety profile of dosages, to establish the most efficient way of administration, and bioavailability, in order to maximize the beneficial effects already discovered, and to ensure replicability. Thus, nutrition represents a promising tool to be used not only in cancer prevention, but hopefully also in cancer treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 16% |
Student > Bachelor | 10 | 16% |
Student > Master | 8 | 13% |
Researcher | 5 | 8% |
Student > Doctoral Student | 4 | 6% |
Other | 9 | 14% |
Unknown | 18 | 28% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 20% |
Nursing and Health Professions | 7 | 11% |
Medicine and Dentistry | 7 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 8% |
Agricultural and Biological Sciences | 4 | 6% |
Other | 4 | 6% |
Unknown | 24 | 38% |