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Cancer Epigenetics for Precision Medicine

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Cover of 'Cancer Epigenetics for Precision Medicine'

Table of Contents

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    Book Overview
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    Chapter 1 Early Epigenetic Markers for Precision Medicine
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    Chapter 2 Interplay Between Genetic and Epigenetic Changes in Breast Cancer Subtypes
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    Chapter 3 Role of Microbiome in Carcinogenesis Process and Epigenetic Regulation of Colorectal Cancer
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    Chapter 4 Epigenome-Based Precision Medicine in Lung Cancer
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    Chapter 4 Review on Current Trends of Deep Learning
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    Chapter 5 Epigenetics in Hematological Malignancies
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    Chapter 6 MicroRNAs Role in Prostate Cancer
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    Chapter 7 Effects of Dietary Nutrients on Epigenetic Changes in Cancer
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    Chapter 8 Diet, Microbiome, and Epigenetics in the Era of Precision Medicine
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    Chapter 9 Alcohol-Induced Epigenetic Changes in Cancer
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    Chapter 10 Epigenetic Basis of Circadian Rhythm Disruption in Cancer
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    Chapter 11 Epigenetic Changes of the Immune System with Role in Tumor Development
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    Chapter 12 DNA Methylation as a Biomarker of Aging in Epidemiologic Studies
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    Chapter 13 Challenges and Opportunities in Social Epigenomics and Cancer
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    Chapter 14 Epigenetic and Genetic Regulation of PDCD1 Gene in Cancer Immunology
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    Chapter 15 Methylation and MicroRNA Profiling to Understand Racial Disparities of Prostate Cancer
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    Chapter 16 Analysis of DNA Hypermethylation in Pancreatic Cancer Using Methylation-Specific PCR and Bisulfite Sequencing
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    Chapter 17 Pyrosequencing Methylation Analysis
Attention for Chapter 16: Analysis of DNA Hypermethylation in Pancreatic Cancer Using Methylation-Specific PCR and Bisulfite Sequencing
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Chapter title
Analysis of DNA Hypermethylation in Pancreatic Cancer Using Methylation-Specific PCR and Bisulfite Sequencing
Chapter number 16
Book title
Cancer Epigenetics for Precision Medicine
Published in
Methods in molecular biology, September 2018
DOI 10.1007/978-1-4939-8751-1_16
Pubmed ID
Book ISBNs
978-1-4939-8750-4, 978-1-4939-8751-1
Authors

Bin Liu, Christian Pilarsky

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor and the fourth common cause of cancer death in the Western world. The lack of effective therapeutic strategies is attributed to the late diagnosis of this disease. Methylation markers could improve early detection and help in the surveillance of PDAC after treatment. Analysis of hypermethylation in the tumor tissue and tumor-derived exosomes might help to identify new therapeutic strategies and aid in the understanding of the pathophysiological changes occurring in pancreatic cancer. There are several methods for the detection of methylation events. Whereas methylation-specific PCR (MSP-PCR) is the method of choice, the cost reductions in DNA sequencing enables researchers to add bisulfite sequencing (BSS) to their repertoire if a small number of genes will be tested in a larger set of patients' samples. During the last years, several techniques to isolate and analyze DNA methylation have been proposed, but DNA modification using sodium bisulfite is still the gold standard.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 29%
Unspecified 1 7%
Lecturer > Senior Lecturer 1 7%
Lecturer 1 7%
Other 1 7%
Other 2 14%
Unknown 4 29%
Readers by discipline Count As %
Medicine and Dentistry 5 36%
Biochemistry, Genetics and Molecular Biology 3 21%
Nursing and Health Professions 1 7%
Unspecified 1 7%
Unknown 4 29%