Chapter title |
Role of Microbiome in Carcinogenesis Process and Epigenetic Regulation of Colorectal Cancer
|
---|---|
Chapter number | 3 |
Book title |
Cancer Epigenetics for Precision Medicine
|
Published in |
Methods in molecular biology, September 2018
|
DOI | 10.1007/978-1-4939-8751-1_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-8750-4, 978-1-4939-8751-1
|
Authors |
Lulu Farhana, Hirendra Nath Banerjee, Mukesh Verma, Adhip P. N. Majumdar, Farhana, Lulu, Banerjee, Hirendra Nath, Verma, Mukesh, Majumdar, Adhip P. N. |
Abstract |
Epigenetic changes during the development of colorectal cancer (CRC) play a significant role. Along with factors such as diet, lifestyle, and genetics, oncogenic infection, bacteria alone or whole microbiome, has been associated with this tumor type. How gut microbiome contributes to CRC pathogenesis in the host is not fully understood. Most of the epigenetic studies in CRC have been conducted in populations infected with Helicobacter pylori. In the current review, we summarize how the gut microbiota contributes in colon carcinogenesis and the potential role of epigenetic mechanism in gene regulation. We discuss microbiota-mediated initiation and progression of colon tumorigenesis and have also touched upon the role of microbial metabolites as an initiator or an inhibitor for procarcinogenic or antioncogenic activities. The hypothesis of gut microbiota associated CRC revealed the dynamic and complexity of microbial interaction in initiating the development of CRC. In the multifaceted processes of colonic carcinogenesis, gradual alteration of microbiota along with their microenvironment and the potential oncopathogenic microbes mediated modulation of cancer therapy and other factors involved in microbiome dysbiosis leading to the CRC have also been discussed. This review provides a comprehensive summary of the mechanisms of CRC development, the role of microbiome or single bacterial infection in regulating the processes of carcinogenesis, and the intervention by novel therapeutics. Epigenetic mechanism involved in CRC is also discussed. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 14% |
Student > Ph. D. Student | 9 | 13% |
Student > Master | 7 | 10% |
Other | 6 | 9% |
Student > Doctoral Student | 4 | 6% |
Other | 8 | 11% |
Unknown | 26 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 15 | 21% |
Medicine and Dentistry | 13 | 19% |
Agricultural and Biological Sciences | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Nursing and Health Professions | 2 | 3% |
Other | 3 | 4% |
Unknown | 29 | 41% |