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TALENs

Overview of attention for book
Cover of 'TALENs'

Table of Contents

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    Book Overview
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    Chapter 1 TALENs
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    Chapter 2 TAL Effector DNA-Binding Principles and Specificity.
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    Chapter 3 The Development of TALE Nucleases for Biotechnology.
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    Chapter 4 Online Tools for TALEN Design
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    Chapter 5 Assembly of Customized TAL Effectors Through Advanced ULtiMATE System
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    Chapter 6 Engineering Customized TALENs Using the Platinum Gate TALEN Kit
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    Chapter 7 Design, Assembly, and Characterization of TALE-Based Transcriptional Activators and Repressors.
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    Chapter 8 A New Approach to Dissect Nuclear Organization: TALE-Mediated Genome Visualization (TGV).
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    Chapter 9 TALEN-Induced Translocations in Human Cells
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    Chapter 10 Mutagenesis in Newts: Protocol for Iberian Ribbed Newts
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    Chapter 11 TALENs
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    Chapter 12 GeneKnockout by Targeted Mutagenesis in a Hemimetabolous Insect, the Two-Spotted Cricket Gryllus bimaculatus , using TALENs
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    Chapter 13 Methods for TALEN Evaluation, Use, and Mutation Detection in the Mosquito Aedes aegypti
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    Chapter 14 Methods for TALEN-Mediated Genomic Manipulations in Drosophila.
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    Chapter 15 Targeted Mutagenesis in Zebrafish by TALENs
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    Chapter 16 Mutagenesis in Xenopus and Zebrafish using TALENs
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    Chapter 17 Genome Editing in Mice Using TALE Nucleases.
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    Chapter 18 Genome Editing in Rats Using TALE Nucleases
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    Chapter 19 Designer Nuclease-Mediated Generation of Knockout THP1 Cells
Attention for Chapter 3: The Development of TALE Nucleases for Biotechnology.
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Chapter title
The Development of TALE Nucleases for Biotechnology.
Chapter number 3
Book title
TALENs
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-2932-0_3
Pubmed ID
26443211
Book ISBNs
978-1-4939-2931-3, 978-1-4939-2932-0
Authors

Ousterout, David G, Gersbach, Charles A, Ousterout, David G., Gersbach, Charles A., David G. Ousterout, Charles A. Gersbach

Abstract

The development of a facile genome engineering technology based on transcription activator-like effector nucleases (TALENs) has led to significant advances in diverse areas of science and medicine. In this review, we provide a broad overview of the development of TALENs and the use of this technology in basic science, biotechnology, and biomedical applications. This includes the discovery of DNA recognition by TALEs, engineering new TALE proteins to diverse targets, general advances in nuclease-based editing strategies, and challenges that are specific to various applications of the TALEN technology. We review examples of applying TALENs for studying gene function and regulation, generating disease models, and developing gene therapies. The current status of genome editing and future directions for other uses of these technologies are also discussed.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Philippines 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 23%
Researcher 8 15%
Student > Master 7 13%
Student > Ph. D. Student 5 9%
Student > Doctoral Student 3 6%
Other 3 6%
Unknown 15 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 34%
Agricultural and Biological Sciences 15 28%
Medicine and Dentistry 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Neuroscience 1 2%
Other 0 0%
Unknown 15 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2015.
All research outputs
#18,428,159
of 22,829,683 outputs
Outputs from Methods in molecular biology
#7,918
of 13,125 outputs
Outputs of similar age
#284,418
of 393,540 outputs
Outputs of similar age from Methods in molecular biology
#846
of 1,470 outputs
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So far Altmetric has tracked 13,125 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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