Chapter title |
The Notch Interactome: Complexity in Signaling Circuitry
|
---|---|
Chapter number | 7 |
Book title |
Molecular Mechanisms of Notch Signaling
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-89512-3_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-989511-6, 978-3-31-989512-3
|
Authors |
Diana M. Ho, K. G. Guruharsha, Spyros Artavanis-Tsakonas |
Abstract |
The Notch pathway controls a very broad spectrum of cell fates in metazoans during development, influencing proliferation, differentiation and cell death. Given its central role in normal development and homeostasis, misregulation of Notch signals can lead to various disorders including cancer. How the Notch pathway mediates such pleiotropic and differential effects is of fundamental importance. It is becoming increasingly clear through a number of large-scale genetic and proteomic studies that Notch interacts with a staggeringly large number of other genes and pathways in a context-dependent, complex, and highly regulated network, which determines the ultimate biological outcome. How best to interpret and analyze the continuously increasing wealth of data on Notch interactors remains a challenge. Here we review the current state of genetic and proteomic data related to the Notch interactome. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 18% |
Student > Ph. D. Student | 2 | 18% |
Lecturer > Senior Lecturer | 1 | 9% |
Student > Master | 1 | 9% |
Researcher | 1 | 9% |
Other | 1 | 9% |
Unknown | 3 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 45% |
Computer Science | 1 | 9% |
Neuroscience | 1 | 9% |
Medicine and Dentistry | 1 | 9% |
Unknown | 3 | 27% |