| Chapter title |
Notch and Neurogenesis
|
|---|---|
| Chapter number | 11 |
| Book title |
Molecular Mechanisms of Notch Signaling
|
| Published in |
Advances in experimental medicine and biology, January 2018
|
| DOI | 10.1007/978-3-319-89512-3_11 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-989511-6, 978-3-31-989512-3
|
| Authors |
Anna Engler, Runrui Zhang, Verdon Taylor, Engler, Anna, Zhang, Runrui, Taylor, Verdon |
| Abstract |
Neurogenesis is the process of forming neurons and is essential during vertebrate development to produce most of the neurons of the adult brain. However, neurogenesis continues throughout life at distinct locations in the vertebrate brain. Neural stem cells (NSCs) are the origin of both embryonic and adult neurogenesis, but their activity and fate are tightly regulated by their local milieu or niche. In this chapter, we will discuss the role of Notch signaling in the control of neurogenesis and regeneration in the embryo and adult. Notch-dependence is a common feature among NSC populations, we will discuss how differences in Notch signaling might contribute to heterogeneity among adult NSCs. Understanding the fate of multiple NSC populations with distinct functions could be important for effective brain regeneration. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 123 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 17% |
| Student > Master | 20 | 16% |
| Researcher | 15 | 12% |
| Student > Bachelor | 14 | 11% |
| Professor > Associate Professor | 8 | 7% |
| Other | 16 | 13% |
| Unknown | 29 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 24% |
| Agricultural and Biological Sciences | 24 | 20% |
| Neuroscience | 17 | 14% |
| Medicine and Dentistry | 5 | 4% |
| Immunology and Microbiology | 3 | 2% |
| Other | 11 | 9% |
| Unknown | 33 | 27% |