Chapter title |
The Molecular Mechanism of Notch Activation
|
---|---|
Chapter number | 3 |
Book title |
Molecular Mechanisms of Notch Signaling
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-89512-3_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-989511-6, 978-3-31-989512-3
|
Authors |
Klaus N. Lovendahl, Stephen C. Blacklow, Wendy R. Gordon |
Abstract |
Research in the last several years has shown that Notch proteolysis, and thus Notch activation, is conformationally controlled by the extracellular juxtamembrane NRR of Notch, which sterically occludes the S2 protease site until ligand binds. The question of how conformational exposure of the protease site is achieved during physiologic activation, and thus how normal activation is bypassed in disease pathogenesis, has been the subject of intense study in the last several years, and is the subject of this chapter. Here, we summarize the structural features of the NRR domains of Notch receptors that establish the autoinhibited state and then review a number of recent studies aimed at testing the mechanotransduction model for Notch signaling using force spectroscopy and molecular tension sensors. |
Mendeley readers
Geographical breakdown
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Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 31% |
Student > Bachelor | 9 | 20% |
Student > Master | 4 | 9% |
Researcher | 4 | 9% |
Other | 2 | 4% |
Other | 6 | 13% |
Unknown | 6 | 13% |
Readers by discipline | Count | As % |
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Chemistry | 2 | 4% |
Computer Science | 1 | 2% |
Other | 6 | 13% |
Unknown | 8 | 18% |