'Validated' pain target, but with clinical implementation failures - multiple actually. here's an overview from @genentech summarizing the challenges: https://t.co/5BuhxGvdNN
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https://t.co/v3hFNQ7axf 💊 3 binding sites with potential for Nav1.7-selective inhibitors: (1) pore extracellular vestibule, (2) extracellular loops of voltage-sensor domain II (VSD2), (3) extracellular loops of voltage-sensor domain IV (VSD4). 📚#extracellu
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Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain. https://t.co/8Jbx8VRQJI
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Translational Model Systems for Complex Sodium Channel Pathophysiology in Pain. https://t.co/UXuCQkdlE4 https://t.co/EMzqpNxSMG